Deepa Nair1,2, Burhanuddin Qayyumi3,4, Florida Sharin3,4, Manish Mair3,4, Munita Bal4,5, Sharmila Pimple4,6, Gauravi Mishra4,6, Sudhir Nair3,4, Pankaj Chaturvedi3,4. 1. Department of Head and Neck Surgical Oncology, Tata Memorial Hospital, TMC, Dr. E Borges Road, Parel, Mumbai, 400012, India. drdeepanair@hotmail.com. 2. Homi Bhabha National Institute, Mumbai, India. drdeepanair@hotmail.com. 3. Department of Head and Neck Surgical Oncology, Tata Memorial Hospital, TMC, Dr. E Borges Road, Parel, Mumbai, 400012, India. 4. Homi Bhabha National Institute, Mumbai, India. 5. Department of Pathology, Tata Memorial Hospital, TMC, Mumbai, India. 6. Preventive Oncology, Tata Memorial Hospital, TMC, Mumbai, India.
Abstract
BACKGROUND: Narrow band imaging (NBI) is a novel method with the potential to improve the diagnostic capability of white-light. METHODS: A prospective observational study of 50 consecutive patients, with suspicious malignant/premalignant lesions. White-light images were assessed as suspicious for malignancy/negative for malignancy, whereas NBI images were classified based on the IPCL patterns. All lesions underwent biopsy and accuracy was compared with the histopathology (Fig. 1). Fig. 1 Representative images of the IPCL patterns from Types I-IV RESULTS: 25 lesions (49%) were positive for malignancy, 2 (3.9%) lesions showed severe dysplasia, and 24(47%) were considered negative on histopathology. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of white light and NBI in detecting invasive carcinoma was 74.07%, 79.17%, 80.00%, 73.08% and 76.47%, and 92.67%, 90.16%, 92.56%, 91.67% and 92.16% respectively. The NBI group had a significantly better sensitivity and specificity to white light. The interobserver concordance was κ = 0.881. CONCLUSION: NBI is a highly effective tool to detect invasive carcinomas amongst suspicious lesions of the oral cavity.
BACKGROUND: Narrow band imaging (NBI) is a novel method with the potential to improve the diagnostic capability of white-light. METHODS: A prospective observational study of 50 consecutive patients, with suspicious malignant/premalignant lesions. White-light images were assessed as suspicious for malignancy/negative for malignancy, whereas NBI images were classified based on the IPCL patterns. All lesions underwent biopsy and accuracy was compared with the histopathology (Fig. 1). Fig. 1 Representative images of the IPCL patterns from Types I-IV RESULTS: 25 lesions (49%) were positive for malignancy, 2 (3.9%) lesions showed severe dysplasia, and 24(47%) were considered negative on histopathology. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of white light and NBI in detecting invasive carcinoma was 74.07%, 79.17%, 80.00%, 73.08% and 76.47%, and 92.67%, 90.16%, 92.56%, 91.67% and 92.16% respectively. The NBI group had a significantly better sensitivity and specificity to white light. The interobserver concordance was κ = 0.881. CONCLUSION: NBI is a highly effective tool to detect invasive carcinomas amongst suspicious lesions of the oral cavity.
Entities:
Keywords:
Early detection oral cancer; NBI in premalignant disorders; NBI oral cancer; NBI vs white light; Narrow band imaging
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