| Literature DB >> 33418181 |
Jingfang Lin1, Chen Li2, Aiqing Li1, Xu Liu1, Chu Chen3, Xue Gong1, Dong Zhou1, Zhen Hong4.
Abstract
Long-term cognitive and neuropsychiatric outcomes of anti-gamma-aminobutyric-acid B receptor (anti-GABABR) encephalitis are unclear. In this prospective study, 31 patients with anti-GABABR encephalitis were underwent cognitive and neuropsychiatric evaluations every 6 months. At 24 months' follow-up, cognitive impairments were observed in 80% of patients that mainly included deficits in memory, executive functions and nonverbal reasoning; and neuropsychiatric symptoms were observed in 50% of patients that mainly included depressive symptoms and irritation. The risk factors associated with cognitive deficits was age > 45 years. This study demonstrated that most patients with anti-GABABR encephalitis had persistent cognitive deficits and neuropsychiatric symptoms.Entities:
Keywords: Anti-GABA(B)R encephalitis; Cognitive deficits; Neuropsychiatric symptoms; Neuropsychological tests
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Year: 2020 PMID： 33418181 DOI： 10.1016/j.jneuroim.2020.577471
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478