Literature DB >> 33417890

Breaking the Rules: Protein Sculpting in NEIL2 Regulation.

Susan E Tsutakawa1, Altaf H Sarker2.   

Abstract

The canonical DNA glycosylase role is global base damage repair but includes functions in epigenetic gene regulation, immune response modulation, replication, and transcription. In this issue of Structure, Eckenroth et al. (2020) present the NEIL2 glycosylase structure. Its catalytic domain flexibility differentiates it from most other glycosylases and suggests novel regulatory mechanisms.
Copyright © 2020 Elsevier Ltd. All rights reserved.

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Year:  2021        PMID： 33417890      PMCID： PMC7909728          DOI： 10.1016/j.str.2020.12.011

Source DB:  PubMed          Journal:  Structure        ISSN： 0969-2126            Impact factor:   5.006


  19 in total

1.  Structural and functional characterization of two unusual endonuclease III enzymes from Deinococcus radiodurans.

Authors:  Aili Sarre; Mats Ökvist; Tobias Klar; David R Hall; Arne O Smalås; Sean McSweeney; Joanna Timmins; Elin Moe
Journal:  J Struct Biol       Date:  2015-07-11       Impact factor: 2.867

2.  Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA.

Authors:  Tapas K Hazra; Tadahide Izumi; Istvan Boldogh; Barry Imhoff; Yoke W Kow; Pawel Jaruga; Miral Dizdaroglu; Sankar Mitra
Journal:  Proc Natl Acad Sci U S A       Date:  2002-03-19       Impact factor: 11.205

3.  DNA bending and a flip-out mechanism for base excision by the helix-hairpin-helix DNA glycosylase, Escherichia coli AlkA.

Authors:  T Hollis; Y Ichikawa; T Ellenberger
Journal:  EMBO J       Date:  2000-02-15       Impact factor: 11.598

4.  Structural and biochemical studies of a plant formamidopyrimidine-DNA glycosylase reveal why eukaryotic Fpg glycosylases do not excise 8-oxoguanine.

Authors:  Stéphanie Duclos; Pierre Aller; Pawel Jaruga; Miral Dizdaroglu; Susan S Wallace; Sylvie Doublié
Journal:  DNA Repair (Amst)       Date:  2012-07-11

5.  Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA.

Authors:  S S Parikh; C D Mol; G Slupphaug; S Bharati; H E Krokan; J A Tainer
Journal:  EMBO J       Date:  1998-09-01       Impact factor: 11.598

6.  The C-terminal lysine of Ogg2 DNA glycosylases is a major molecular determinant for guanine/8-oxoguanine distinction.

Authors:  Frédérick Faucher; Susan S Wallace; Sylvie Doublié
Journal:  J Mol Biol       Date:  2010-01-18       Impact factor: 5.469

7.  Crystal structures of two archaeal 8-oxoguanine DNA glycosylases provide structural insight into guanine/8-oxoguanine distinction.

Authors:  Frédérick Faucher; Stéphanie Duclos; Viswanath Bandaru; Susan S Wallace; Sylvie Doublié
Journal:  Structure       Date:  2009-05-13       Impact factor: 5.006

8.  Stimulation of NEIL2-mediated oxidized base excision repair via YB-1 interaction during oxidative stress.

Authors:  Soumita Das; Ranajoy Chattopadhyay; Kishor K Bhakat; Istvan Boldogh; Kimitoshi Kohno; Rajendra Prasad; Samuel H Wilson; Tapas K Hazra
Journal:  J Biol Chem       Date:  2007-08-07       Impact factor: 5.157

9.  Neil2-null Mice Accumulate Oxidized DNA Bases in the Transcriptionally Active Sequences of the Genome and Are Susceptible to Innate Inflammation.

Authors:  Anirban Chakraborty; Maki Wakamiya; Tatiana Venkova-Canova; Raj K Pandita; Leopoldo Aguilera-Aguirre; Altaf H Sarker; Dharmendra Kumar Singh; Koa Hosoki; Thomas G Wood; Gulshan Sharma; Victor Cardenas; Partha S Sarkar; Sanjiv Sur; Tej K Pandita; Istvan Boldogh; Tapas K Hazra
Journal:  J Biol Chem       Date:  2015-08-05       Impact factor: 5.157

10.  Heritable pattern of oxidized DNA base repair coincides with pre-targeting of repair complexes to open chromatin.

Authors:  Albino Bacolla; Shiladitya Sengupta; Zu Ye; Chunying Yang; Joy Mitra; Ruth B De-Paula; Muralidhar L Hegde; Zamal Ahmed; Matthew Mort; David N Cooper; Sankar Mitra; John A Tainer
Journal:  Nucleic Acids Res       Date:  2021-01-11       Impact factor: 16.971
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  1 in total

1.  Universally Accessible Structural Data on Macromolecular Conformation, Assembly, and Dynamics by Small Angle X-Ray Scattering for DNA Repair Insights.

Authors:  Naga Babu Chinnam; Aleem Syed; Kathryn H Burnett; Greg L Hura; John A Tainer; Susan E Tsutakawa
Journal:  Methods Mol Biol       Date:  2022
  1 in total

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