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Literature DB >> 33417864

The Rise of Molecular Glues.

Abstract

2021 marks the 30th anniversary of the revelation that cyclosporin A and FK506 act in a way previously not seen-as "molecular glues" that induce neo-protein-protein associations. As a torrent of new molecular-glue probes and medicines are fueling interest in this field, I explore the arc of this story.

Entities: Chemical

Year: 2021 PMID： 33417864 DOI： 10.1016/j.cell.2020.12.020

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

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Cited

41 in total

Review 1. Advances in targeting 'undruggable' transcription factors with small molecules.

Authors: Matthew J Henley; Angela N Koehler
Journal: Nat Rev Drug Discov Date: 2021-05-18 Impact factor: 84.694

Review 2. The different autophagy degradation pathways and neurodegeneration.

Authors: Angeleen Fleming; Mathieu Bourdenx; Motoki Fujimaki; Cansu Karabiyik; Gregory J Krause; Ana Lopez; Adrián Martín-Segura; Claudia Puri; Aurora Scrivo; John Skidmore; Sung Min Son; Eleanna Stamatakou; Lidia Wrobel; Ye Zhu; Ana Maria Cuervo; David C Rubinsztein
Journal: Neuron Date: 2022-02-07 Impact factor: 17.173

3. PROTACs technology for treatment of Alzheimer's disease: Advances and perspectives.

Authors: Hiroyuki Inuzuka; Jing Liu; Wenyi Wei; Abdol-Hossein Rezaeian
Journal: Acta Mater Med Date: 2022-01-21

4. Characterization of In Vivo Protein Complexes via Chemical Cross-Linking and Mass Spectrometry.

Authors: Yuefan Wang; Yingwei Hu; Naseruddin Höti; Lan Huang; Hui Zhang
Journal: Anal Chem Date: 2021-12-28 Impact factor: 6.986

Review 5. Evolution of 3-(4-hydroxyphenyl)indoline-2-one as a scaffold for potent and selective anticancer activity.

Authors: Matthew W Boudreau; Paul J Hergenrother
Journal: RSC Med Chem Date: 2022-05-09

6. Exploring Ligand-Directed N-Acyl-N-alkylsulfonamide-Based Acylation Chemistry for Potential Targeted Degrader Development.

Authors: Mingxing Teng; Jie Jiang; Scott B Ficarro; Hyuk-Soo Seo; Jae Hyun Bae; Katherine A Donovan; Eric S Fischer; Tinghu Zhang; Sirano Dhe-Paganon; Jarrod A Marto; Nathanael S Gray
Journal: ACS Med Chem Lett Date: 2021-07-21 Impact factor: 4.632

The Rise of Molecular Glues.

Review 1. Advances in targeting 'undruggable' transcription factors with small molecules.

Review 2. The different autophagy degradation pathways and neurodegeneration.

3. PROTACs technology for treatment of Alzheimer's disease: Advances and perspectives.

4. Characterization of In Vivo Protein Complexes via Chemical Cross-Linking and Mass Spectrometry.

Review 5. Evolution of 3-(4-hydroxyphenyl)indoline-2-one as a scaffold for potent and selective anticancer activity.

6. Exploring Ligand-Directed N-Acyl-N-alkylsulfonamide-Based Acylation Chemistry for Potential Targeted Degrader Development.

7. SPIN4 Is a Principal Endogenous Substrate of the E3 Ubiquitin Ligase DCAF16.

8. Ligandability of E3 Ligases for Targeted Protein Degradation Applications.

9. Development of MDM2 degraders based on ligands derived from Ugi reactions: Lessons and discoveries.

10. Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions.