| Literature DB >> 33417276 |
Frode Norheim1,2, Karthickeyan Chella Krishnan1, Thomas Bjellaas3, Laurent Vergnes4, Calvin Pan1, Brian W Parks5, Yonghong Meng1, Jennifer Lang1, James A Ward1, Karen Reue4, Margarete Mehrabian1, Thomas E Gundersen3, Miklós Péterfy1,6, Knut T Dalen2, Christian A Drevon2,3, Simon T Hui1, Aldons J Lusis1,4, Marcus M Seldin1,7.
Abstract
To elucidate the contributions of specific lipid species to metabolic traits, we integrated global hepatic lipid data with other omics measures and genetic data from a cohort of about 100 diverse inbred strains of mice fed a high-fat/high-sucrose diet for 8 weeks. Association mapping, correlation, structure analyses, and network modeling revealed pathways and genes underlying these interactions. In particular, our studies lead to the identification of Ifi203 and Map2k6 as regulators of hepatic phosphatidylcholine homeostasis and triacylglycerol accumulation, respectively. Our analyses highlight mechanisms for how genetic variation in hepatic lipidome can be linked to physiological and molecular phenotypes, such as microbiota composition.Entities:
Keywords: Hybrid Mouse Diversity Panel; genome-wide association studies; hepatic lipidome; non-alcoholic fatty liver disease; quantitative trait loci for lipids
Year: 2021 PMID： 33417276 PMCID： PMC7792507 DOI： 10.15252/msb.20209684
Source DB: PubMed Journal: Mol Syst Biol ISSN： 1744-4292 Impact factor: 11.429