Marta Bodro1, Marta Hernández-Meneses1, Juan Ambrosioni2, Laura Linares1, Asunción Moreno1, Elena Sandoval3, Pol Olivas4, María Hernández-Tejero4, José M Miró1, Francesc Marco5, Alex Soriano1. 1. Department of Infectious Diseases, Hospital Clínic-IDIBAPS, University of Barcelona, Barcelona, Spain. 2. Department of Infectious Diseases, Hospital Clínic-IDIBAPS, University of Barcelona, Barcelona, Spain. jambrosioni@intramed.net. 3. Department of Cardiovascular Surgery, Hospital Clínic-IDIBAPS, University of Barcelona, Barcelona, Spain. 4. Department of Hepatology. Hospital Clínic-IDIBAPS, University of Barcelona, Barcelona, Spain. 5. Microbiology Laboratory, CDB, ISGlobal, Hospital Clínic-IDIBAPS, University of Barcelona, Barcelona, Spain.
Abstract
INTRODUCTION: The objective of this study was to describe two challenging cases of intravascular foreign body infections caused by multidrug-resistant Gram-negative pathogens requiring complex antimicrobial regimens including cefiderocol and successfully treated without implant removal. METHODS: Clinical charts and microbiological reports of the clinical cases. RESULTS: Case 1 included a left ventricular assist device (HEARTMATE 3™Abbot®) infection due to Achromobacter xylosoxidans, while case 2 included a portal prosthesis infection due to Pseudomonas aeruginosa. As the pathogens were multidrug-resistant (MDR), both cases required antimicrobial regimens with cefiderocol; treatment was successful without implant removal. Importantly, case 1 presented a probable, drug-induced thrombocytopenia, a non-previously described side effect related to cefiderocol. CONCLUSION: Cefiderocol may be an additional, promising drug to the available arsenal, even for challenging foreign body infections caused by MDR Gram-negative pathogens.
INTRODUCTION: The objective of this study was to describe two challenging cases of intravascular foreign body infections caused by multidrug-resistant Gram-negative pathogens requiring complex antimicrobial regimens including cefiderocol and successfully treated without implant removal. METHODS: Clinical charts and microbiological reports of the clinical cases. RESULTS: Case 1 included a left ventricular assist device (HEARTMATE 3™Abbot®) infection due to Achromobacter xylosoxidans, while case 2 included a portal prosthesis infection due to Pseudomonas aeruginosa. As the pathogens were multidrug-resistant (MDR), both cases required antimicrobial regimens with cefiderocol; treatment was successful without implant removal. Importantly, case 1 presented a probable, drug-induced thrombocytopenia, a non-previously described side effect related to cefiderocol. CONCLUSION:Cefiderocol may be an additional, promising drug to the available arsenal, even for challenging foreign body infections caused by MDR Gram-negative pathogens.
Entities:
Keywords:
Cefiderocol; Foreign body infections; Gram-negative bacteria; Multidrug resistance
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