Jaime López-Sánchez1,2, Carmen Esteban1,2, Manuel J Iglesias1,2, Luis M González1,2, José E Quiñones1,2, Juan I González-Muñoz1,2, Guadalupe Tabernero3, Rosa A Iglesias4, Pilar Fraile3, Javier I Muñoz-González2,5, Luis Muñoz-Bellvís6,7,8. 1. Department of General and Gastrointestinal Surgery, Pancreas Transplant Program, Hospital Universitario de Salamanca, Salamanca, Spain. 2. Biomedical Research Institute of Salamanca (IBSAL), Universidad de Salamanca, Salamanca, Spain. 3. Department of Nephrology, Hospital Universitario de Salamanca, Salamanca, Spain. 4. Department of Endocrinology, Hospital Universitario de Salamanca, Salamanca, Spain. 5. Cancer Research Center (IBMCC, USAL-CSIC), Department of Medicine and Cytometry Service (NUCLEUS), Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Universidad de Salamanca, Salamanca, Spain. 6. Department of General and Gastrointestinal Surgery, Pancreas Transplant Program, Hospital Universitario de Salamanca, Salamanca, Spain. luismb@usal.es. 7. Biomedical Research Institute of Salamanca (IBSAL), Universidad de Salamanca, Salamanca, Spain. luismb@usal.es. 8. Department of Surgery, Hospital Universitario de Salamanca, Paseo San Vicente, 88-132, 37007, Salamanca, Spain. luismb@usal.es.
Abstract
PURPOSE: Pancreas transplantation (PT) is one of the few ways to restore euglycemia within diabetic patients; however, the high morbidity caused by surgical complications and the need for immunosuppressive therapy has raised controversy about PT improving the health-related quality-of-life (HRQoL). The aim of this study is to assess the long-term (≥ 5 years after PT) HRQoL and to identify the factors affecting it. METHODS: A single-center, cross-sectional study of 49 sequential PT was performed. All patients conducted a telephone interview to fulfill the modification of Medical Outcome Health Survey Short Form questionnaire (SF-36v2) and were compared to similar post-PT studies from the literature. RESULTS: Patients with a history of replacement renal therapy (RRT) or neuropathy undergoing a PT were associated to a worse bodily pain (P = 0.03) and physical function (P = 0.04), respectively, whereas those with retinopathy showed an improved Role Emotional (P = 0.04). Multivariate analysis revealed the presence of RRT as the only independent prognostic factor for a worse bodily pain [relative risk = 3.9; 95% confidence interval (1.1-14.6)], (P = 0.04). Furthermore, nearly all PT recipients (91.8%) claimed an overall better health than prior to PT. CONCLUSION: Our study confirms that PT recipients' HRQoL improves after PT, showing similar HRQoL scores across different populations and suggests that patients in predialysis could benefit from an improved HRQoL if transplanted on the early stages of the disease.
PURPOSE: Pancreas transplantation (PT) is one of the few ways to restore euglycemia within diabeticpatients; however, the high morbidity caused by surgical complications and the need for immunosuppressive therapy has raised controversy about PT improving the health-related quality-of-life (HRQoL). The aim of this study is to assess the long-term (≥ 5 years after PT) HRQoL and to identify the factors affecting it. METHODS: A single-center, cross-sectional study of 49 sequential PT was performed. All patients conducted a telephone interview to fulfill the modification of Medical Outcome Health Survey Short Form questionnaire (SF-36v2) and were compared to similar post-PT studies from the literature. RESULTS:Patients with a history of replacement renal therapy (RRT) or neuropathy undergoing a PT were associated to a worse bodily pain (P = 0.03) and physical function (P = 0.04), respectively, whereas those with retinopathy showed an improved Role Emotional (P = 0.04). Multivariate analysis revealed the presence of RRT as the only independent prognostic factor for a worse bodily pain [relative risk = 3.9; 95% confidence interval (1.1-14.6)], (P = 0.04). Furthermore, nearly all PT recipients (91.8%) claimed an overall better health than prior to PT. CONCLUSION: Our study confirms that PT recipients' HRQoL improves after PT, showing similar HRQoL scores across different populations and suggests that patients in predialysis could benefit from an improved HRQoL if transplanted on the early stages of the disease.
Authors: David J Cohen; Ben Van Hout; Patrick W Serruys; Friedrich W Mohr; Carlos Macaya; Peter den Heijer; M M Vrakking; Kaijun Wang; Elizabeth M Mahoney; Salma Audi; Katrin Leadley; Keith D Dawkins; A Pieter Kappetein Journal: N Engl J Med Date: 2011-03-17 Impact factor: 91.245
Authors: Luis Muñoz-Bellvis; María Del Carmen Esteban; Manuel Iglesias; Luis González; Juan Ignacio González-Muñoz; Cristina Muñoz-González; José E Quiñones; Guadalupe Tabernero; Rosa Ana Iglesias; José María Sayagués; Pilar Fraile Journal: Cir Esp (Engl Ed) Date: 2018-02-28
Authors: Michael R Rickels; Peter G Stock; Eelco J P de Koning; Lorenzo Piemonti; Johann Pratschke; Rodolfo Alejandro; Melena D Bellin; Thierry Berney; Pratik Choudhary; Paul R Johnson; Raja Kandaswamy; Thomas W H Kay; Bart Keymeulen; Yogish C Kudva; Esther Latres; Robert M Langer; Roger Lehmann; Barbara Ludwig; James F Markmann; Marjana Marinac; Jon S Odorico; François Pattou; Peter A Senior; James A M Shaw; Marie-Christine Vantyghem; Steven White Journal: Transpl Int Date: 2018-04 Impact factor: 3.782