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Literature DB >> 33416026

U1 snRNP telescripting: molecular mechanisms and beyond.

Yi Ran¹, Yanhui Deng¹, Chengguo Yao^1,2.

Abstract

U1 snRNP is one of the most abundant ribonucleoprotein (RNP) complexes in eukaryotic cells and is estimated to be approximately 1 million copies per cell. Apart from its canonical role in mRNA splicing, this complex has emerged as a key regulator of eukaryotic mRNA length via inhibition of mRNA 3'-end processing at numerous intronic polyadenylation sites, in a process that is also termed 'U1 snRNP telescripting'. Several reviews have extensively described the concept of U1 telescripting and subsequently highlighted its potential impacts in mRNA metabolism. Here, we review what is currently known regarding the underlying mechanisms of this important phenomenon and discuss open questions and future challenges.

Entities: Chemical

Keywords: U1 snRNP telescripting; co-transcriptional mRNA processing; mRNA polyadenylation; mRNA splicing; premature cleavage and polyadenylation (PCPA)

Mesh：

Substances：

Year: 2021 PMID： 33416026 PMCID： PMC8583093 DOI： 10.1080/15476286.2021.1872963

Source DB: PubMed Journal: RNA Biol ISSN： 1547-6286 Impact factor: 4.652

113 in total

Review 1. U1 snRNP Telescripting: Suppression of Premature Transcription Termination in Introns as a New Layer of Gene Regulation.

Authors: Christopher C Venters; Jung-Min Oh; Chao Di; Byung Ran So; Gideon Dreyfuss
Journal: Cold Spring Harb Perspect Biol Date: 2019-02-01 Impact factor: 10.005

2. The U1 small nuclear RNA-protein complex selectively binds a 5' splice site in vitro.

Authors: S M Mount; I Pettersson; M Hinterberger; A Karmas; J A Steitz
Journal: Cell Date: 1983-06 Impact factor: 41.582

3. Interaction between the RNA binding domains of Ser-Arg splicing factor 1 and U1-70K snRNP protein determines early spliceosome assembly.

Authors: Suhyung Cho; Amy Hoang; Rahul Sinha; Xiang-Yang Zhong; Xiang-Dong Fu; Adrian R Krainer; Gourisankar Ghosh
Journal: Proc Natl Acad Sci U S A Date: 2011-05-02 Impact factor: 11.205

4. Pcf11 is a termination factor in Drosophila that dismantles the elongation complex by bridging the CTD of RNA polymerase II to the nascent transcript.

Authors: Zhiqiang Zhang; David S Gilmour
Journal: Mol Cell Date: 2006-01-06 Impact factor: 17.970

U1 snRNP telescripting: molecular mechanisms and beyond.

Review 1. U1 snRNP Telescripting: Suppression of Premature Transcription Termination in Introns as a New Layer of Gene Regulation.

2. The U1 small nuclear RNA-protein complex selectively binds a 5' splice site in vitro.

3. Interaction between the RNA binding domains of Ser-Arg splicing factor 1 and U1-70K snRNP protein determines early spliceosome assembly.

4. Pcf11 is a termination factor in Drosophila that dismantles the elongation complex by bridging the CTD of RNA polymerase II to the nascent transcript.

5. Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonuclease.

6. Cooperative interaction of transcription termination factors with the RNA polymerase II C-terminal domain.

7. Isoforms of U1-70k control subunit dynamics in the human spliceosomal U1 snRNP.

Review 8. Transcription and splicing: A two-way street.

9. Landscape and evolution of tissue-specific alternative polyadenylation across Drosophila species.

10. A transcriptome-wide antitermination mechanism sustaining identity of embryonic stem cells.

1. CFIm25 regulates human stem cell function independently of its role in mRNA alternative polyadenylation.