Audrey Damiens1,2, Mohammad Taghi Alebrahim3, Estelle Léonard2, Antoine Fayeulle2, Christophe Furman4,5, Jean-Louis Hilbert6, Ali Siah7, Muriel Billamboz1,4. 1. Laboratoire de Chimie Durable et Santé, Health & Environment Department, Team Sustainable Chemistry, Ecole des Hautes Etudes d'Ingénieur (HEI), Yncréa Hauts-de-France, Lille, France. 2. Université de Technologie de Compiègne, ESCOM, Integrated Transformations of Renewable Matter, Centre de Recherche Royallieu, Compiègne, France. 3. Department of Agronomy and Plant Breeding, Faculty of Agriculture and Natural Resources, University of Mohaghegh Ardabili, Ardabil, Iran. 4. Université de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE - Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France. 5. Institut de Chimie Pharmaceutique Albert Lespagnol, Lille, France. 6. Joint Research Unit BioEcoAgro N° 1158, Université de Lille, Université Liège, UPJV, INRAE, YNCREA, Université d'Artois, Université Littoral Côte d'Opale, ICV Institut Charles Viollette, Lille, France. 7. Agriculture and Landscape Department, Team Plant Pathology and Biocontrol, UMR-Transfrontalière N° 1158 BioEcoAgro, Yncrea Hauts-de-France, ISA, Lille, France.
Abstract
BACKGROUND: Research into environmentally friendly alternatives to conventional plant protection products, to promote sustainable agriculture and healthy food, is strongly encouraged. RESULTS: In this context, 20 naturally occurring terpenoids and phenolic compounds were selected and evaluated in vitro as crop protection compounds against Zymoseptoria tritici, the causal agent of Septoria tritici blotch of wheat. After selection of the most active compounds, some hemisynthetic modifications were conducted to modify their lipophilicity. These modifications led to the discovery of sesamol esters as promising antifungal agents, with IC50 around 10 μg/mL and a total absence of cytotoxicity against human cells. CONCLUSION: These sesamol-based derivatives should be selected for further evaluations in planta to validate their use as wheat crop protection agents. Moreover, the importance of a balanced hydrophily/lipophilicity ratio should be further studied.
BACKGROUND: Research into environmentally friendly alternatives to conventional plant protection products, to promote sustainable agriculture and healthy food, is strongly encouraged. RESULTS: In this context, 20 naturally occurring terpenoids and phenolic compounds were selected and evaluated in vitro as crop protection compounds against Zymoseptoria tritici, the causal agent of Septoria tritici blotch of wheat. After selection of the most active compounds, some hemisynthetic modifications were conducted to modify their lipophilicity. These modifications led to the discovery of sesamol esters as promising antifungal agents, with IC50 around 10 μg/mL and a total absence of cytotoxicity against human cells. CONCLUSION: These sesamol-based derivatives should be selected for further evaluations in planta to validate their use as wheat crop protection agents. Moreover, the importance of a balanced hydrophily/lipophilicity ratio should be further studied.