Literature DB >> 33414987

The role of Pim kinase in immunomodulation.

Zhaoyun Liu1, Mei Han1, Kai Ding1, Rong Fu1.   

Abstract

Pim kinase, which has three isozymes (Pim-1, Pim-2 and Pim-3), is a serine/threonine kinase abnormally expressed in many cancers. High Pim kinase expression has been recognized to be associated with disease progression and prognosis. It is well accepted that Pim kinase is considered a clinical biomarker and potential therapeutic target for tumor cell. In recent years, researches verified the role of Pim kinase in immunomodulation. The mechanisms by which Pim kinase modulates the immune microenvironment and regulates immune cells, as well as the effects of Pim kinase inhibitors on immunity, have not been systematically described. This review comprehensively focuses on the current research status of Pim kinase pathways and the immune regulation. AJCR
Copyright © 2020.

Entities:  

Keywords:  PI3K/Akt/mTOR; Pim kinase; cancer; immune; inhibitors

Year:  2020        PMID： 33414987      PMCID： PMC7783746     

Source DB:  PubMed          Journal:  Am J Cancer Res        ISSN： 2156-6976            Impact factor:   6.166


  98 in total

1.  Expression of PIM kinases in Reed-Sternberg cells fosters immune privilege and tumor cell survival in Hodgkin lymphoma.

Authors:  Maciej Szydłowski; Monika Prochorec-Sobieszek; Anna Szumera-Ciećkiewicz; Edyta Derezińska; Grażyna Hoser; Danuta Wasilewska; Olga Szymańska-Giemza; Ewa Jabłońska; Emilia Białopiotrowicz; Tomasz Sewastianik; Anna Polak; Wojciech Czardybon; Michał Gałęzowski; Renata Windak; Jan Maciej Zaucha; Krzysztof Warzocha; Krzysztof Brzózka; Przemysław Juszczyński
Journal:  Blood       Date:  2017-07-11       Impact factor: 22.113

2.  Pim1 and Myc reversibly transform murine precursor B lymphocytes but not mature B lymphocytes.

Authors:  Corinne Bouquet; Fritz Melchers
Journal:  Eur J Immunol       Date:  2011-12-19       Impact factor: 5.532

3.  Characterization of the human PIM-1 gene: a putative proto-oncogene coding for a tissue specific member of the protein kinase family.

Authors:  T C Meeker; L Nagarajan; A ar-Rushdi; G Rovera; K Huebner; C M Croce
Journal:  Oncogene Res       Date:  1987-06

4.  Evidence implicating Gfi-1 and Pim-1 in pre-T-cell differentiation steps associated with beta-selection.

Authors:  T Schmidt; H Karsunky; B Rödel; B Zevnik; H P Elsässer; T Möröy
Journal:  EMBO J       Date:  1998-09-15       Impact factor: 11.598

5.  c-Myb regulates the proliferation of immature thymocytes following beta-selection.

Authors:  R Pearson; K Weston
Journal:  EMBO J       Date:  2000-11-15       Impact factor: 11.598

6.  Expression of human pim family genes is selectively up-regulated by cytokines promoting T helper type 1, but not T helper type 2, cell differentiation.

Authors:  Teija L T Aho; Riikka J Lund; Emmi K Ylikoski; Sampsa Matikainen; Riitta Lahesmaa; Päivi J Koskinen
Journal:  Immunology       Date:  2005-09       Impact factor: 7.397

7.  Proto-Oncogene Serine/Threonine Kinase PIM3 Promotes Cell Migration via Modulating Rho GTPase Signaling.

Authors:  Yamei Dang; Na Jiang; Hao Wang; Xuechun Chen; Yan Gao; Xiangyang Zhang; Guoxuan Qin; Yongmei Li; Ruibing Chen
Journal:  J Proteome Res       Date:  2020-02-07       Impact factor: 4.466

8.  EBNA3C augments Pim-1 mediated phosphorylation and degradation of p21 to promote B-cell proliferation.

Authors:  Shuvomoy Banerjee; Jie Lu; Qiliang Cai; Zhiguo Sun; Hem Chandra Jha; Erle S Robertson
Journal:  PLoS Pathog       Date:  2014-08-14       Impact factor: 6.823

9.  T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR.

Authors:  Stephan Sauer; Ludovica Bruno; Arnulf Hertweck; David Finlay; Marion Leleu; Mikhail Spivakov; Zachary A Knight; Bradley S Cobb; Doreen Cantrell; Eric O'Connor; Kevan M Shokat; Amanda G Fisher; Matthias Merkenschlager
Journal:  Proc Natl Acad Sci U S A       Date:  2008-05-28       Impact factor: 11.205

10.  Proviral integration site for Moloney murine leukemia virus (PIM) kinases promote human T helper 1 cell differentiation.

Authors:  Johanna Tahvanainen; Minna K Kyläniemi; Kartiek Kanduri; Bhawna Gupta; Hanna Lähteenmäki; Teemu Kallonen; Anna Rajavuori; Omid Rasool; Päivi J Koskinen; Kanury V S Rao; Harri Lähdesmäki; Riitta Lahesmaa
Journal:  J Biol Chem       Date:  2012-12-03       Impact factor: 5.157
View more
  8 in total

Review 1.  A systematic review on active sites and functions of PIM-1 protein.

Authors:  Youyi Zhao; Aziz Ur Rehman Aziz; Hangyu Zhang; Zhengyao Zhang; Na Li; Bo Liu
Journal:  Hum Cell       Date:  2022-01-09       Impact factor: 4.174

2.  Targeting Host PIM Protein Kinases Reduces Mayaro Virus Replication.

Authors:  Madelaine Sugasti-Salazar; Dalkiria Campos; Patricia Valdés-Torres; Paola Elaine Galán-Jurado; José González-Santamaría
Journal:  Viruses       Date:  2022-02-18       Impact factor: 5.048

3.  Multi-omics evaluation of SARS-CoV-2 infected mouse lungs reveals dynamics of host responses.

Authors:  Zhao Ni Wang; Xiang Sheng Yang; Jing Sun; Jin Cun Zhao; Nan Shan Zhong; Xiao Xiao Tang
Journal:  iScience       Date:  2022-02-22

4.  Single-cell RNA sequencing depicts the local cell landscape in thyroid-associated ophthalmopathy.

Authors:  Zhaohuai Li; Mei Wang; Jia Tan; Lei Zhu; Peng Zeng; Xiaozhen Chen; Lihui Xie; Runping Duan; Binyao Chen; Tianyu Tao; Rong Wang; Xianggui Wang; Wenru Su
Journal:  Cell Rep Med       Date:  2022-07-26

5.  Role of PIM2 in acute lung injury induced by sepsis.

Authors:  Juncai Ding; Xiufang Yang; Huijuan Huang; Bo Wang
Journal:  Exp Ther Med       Date:  2022-06-30       Impact factor: 2.751

Review 6.  NF-κB: A Druggable Target in Acute Myeloid Leukemia.

Authors:  Barbara Di Francesco; Daniela Verzella; Daria Capece; Davide Vecchiotti; Mauro Di Vito Nolfi; Irene Flati; Jessica Cornice; Monica Di Padova; Adriano Angelucci; Edoardo Alesse; Francesca Zazzeroni
Journal:  Cancers (Basel)       Date:  2022-07-21       Impact factor: 6.575

7.  Inhibition of CEBPB Attenuates Lupus Nephritis via Regulating Pim-1 Signaling.

Authors:  Xiaoyang Wang; Weili Cheng; Xiaopan Chen; Yanan Gong; Guangjie Wang; Xiaoxue Zhang; Yuanyuan Qi
Journal:  Mediators Inflamm       Date:  2022-09-20       Impact factor: 4.529

8.  Multicellular immune dynamics implicate PIM1 as a potential therapeutic target for uveitis.

Authors:  He Li; Lihui Xie; Lei Zhu; Zhaohuai Li; Rong Wang; Xiuxing Liu; Zhaohao Huang; Binyao Chen; Yuehan Gao; Lai Wei; Chang He; Rong Ju; Yizhi Liu; Xialin Liu; Yingfeng Zheng; Wenru Su
Journal:  Nat Commun       Date:  2022-10-04       Impact factor: 17.694
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.