Literature DB >> 33414769

Extended-Spectrum β-Lactamases in Human Isolates of Multidrug-Resistant Non-typhoidal Salmonella enterica.

Anahit M Sedrakyan1, Zhanna A Ktsoyan1, Karine A Arakelova1, Magdalina K Zakharyan1, Alvard I Hovhannisyan1, Zaruhi U Gevorgyan2, Armine A Mnatsakanyan3, Elene G Kakabadze4,5, Khatuna B Makalatia4,5, Nina A Chanishvili4, Jean-Paul Pirnay6, Arsen A Arakelyan1, Rustam I Aminov7,8.   

Abstract

A total of 291 non-duplicate isolates of non-typhoidal Salmonella (NTS) were collected from the fecal samples of patients with salmonellosis in Armenia and Georgia during 1996-2016. The isolates were tested for resistance to antimicrobials, including extended-spectrum β-lactamases (ESBL). The high prevalence of multidrug-resistance (MDR) and ESBL-producer phenotypes was detected among Salmonella enterica subsp. enterica serovar Typhimurium (S. Typhimurium) isolates collected from patients in Armenia between 1996 and 2016. A total of 36 MDR NTS isolates were subjected to whole genome sequencing (WGS) to determine the genetic background of antimicrobial resistance (AMR) and mobile genetic elements. All ESBL-producing S. Typhimurium isolates belonged to the same sequence type (ST328). The ESBL-producer phenotype was associated with plasmid-encoded CTX-M-5 production. A range of other plasmids was associated with resistance to other antimicrobials, including the MDR phenotype.
Copyright © 2020 Sedrakyan, Ktsoyan, Arakelova, Zakharyan, Hovhannisyan, Gevorgyan, Mnatsakanyan, Kakabadze, Makalatia, Chanishvili, Pirnay, Arakelyan and Aminov.

Entities:  

Keywords:  WGS; antimicrobial resistance; antimicrobial resistance genes; extended-spectrum β-lactamases; non-typhoidal Salmonella

Year:  2020        PMID： 33414769      PMCID： PMC7783090          DOI： 10.3389/fmicb.2020.592223

Source DB:  PubMed          Journal:  Front Microbiol        ISSN： 1664-302X            Impact factor:   5.640


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7.  CTX-M-5, a novel cefotaxime-hydrolyzing beta-lactamase from an outbreak of Salmonella typhimurium in Latvia.

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  2 in total

1.  Molecular Epidemiology and Virulence of Non-Typhoidal Salmonella in Armenia.

Authors:  Anahit Sedrakyan; Zhanna Ktsoyan; Karine Arakelova; Zaruhi Gevorgyan; Magdalina Zakharyan; Shoghik Hakobyan; Alvard Hovhannisyan; Arsen Arakelyan; Rustam Aminov
Journal:  Int J Mol Sci       Date:  2022-08-18       Impact factor: 6.208

2.  Investigation of Salmonella Phage-Bacteria Infection Profiles: Network Structure Reveals a Gradient of Target-Range from Generalist to Specialist Phage Clones in Nested Subsets.

Authors:  Khatuna Makalatia; Elene Kakabadze; Nata Bakuradze; Nino Grdzelishvili; Ben Stamp; Ezra Herman; Avraam Tapinos; Aidan Coffey; David Lee; Nikolaos G Papadopoulos; David L Robertson; Nina Chanishvili; Spyridon Megremis
Journal:  Viruses       Date:  2021-06-28       Impact factor: 5.048
  2 in total

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