| Literature DB >> 33414551 |
Hakon Jonsson1, Erna Magnusdottir2, Hannes P Eggertsson3, Olafur A Stefansson3, Gudny A Arnadottir3, Ogmundur Eiriksson3, Florian Zink3, Einar A Helgason3, Ingileif Jonsdottir3, Arnaldur Gylfason3, Adalbjorg Jonasdottir3, Aslaug Jonasdottir3, Doruk Beyter3, Thora Steingrimsdottir2, Gudmundur L Norddahl3, Olafur Th Magnusson3, Gisli Masson3, Bjarni V Halldorsson3,4, Unnur Thorsteinsdottir3,2, Agnar Helgason3,5, Patrick Sulem3, Daniel F Gudbjartsson6,7, Kari Stefansson8,9.
Abstract
Despite the important role that monozygotic twins have played in genetics research, little is known about their genomic differences. Here we show that monozygotic twins differ on average by 5.2 early developmental mutations and that approximately 15% of monozygotic twins have a substantial number of these early developmental mutations specific to one of them. Using the parents and offspring of twins, we identified pre-twinning mutations. We observed instances where a twin was formed from a single cell lineage in the pre-twinning cell mass and instances where a twin was formed from several cell lineages. CpG>TpG mutations increased in frequency with embryonic development, coinciding with an increase in DNA methylation. Our results indicate that allocations of cells during development shapes genomic differences between monozygotic twins.Year: 2021 PMID： 33414551 DOI： 10.1038/s41588-020-00755-1
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330