Juan M Pericàs1, Juan Ambrosioni2, Patricia Muñoz3, Arístides de Alarcón4, Martha Kestler5, Amaia Mari-Hualde5, Asunción Moreno2, Miguel Á Goenaga6, M Carmen Fariñas7, Regino Rodríguez-Álvarez8, Guillermo Ojeda-Burgos9, Juan Gálvez-Acebal10, Carmen Hidalgo-Tenorio11, Mariam Noureddine9, José M Miró12. 1. Hospital Clínic de Barcelona, IDIBAPS, Universitat de Barcelona, Barcelona, Spain; Vall d'Hebron Institute for Research (VHIR), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain. 2. Hospital Clínic de Barcelona, IDIBAPS, Universitat de Barcelona, Barcelona, Spain. 3. Hospital General Universitario Gregorio Marañón, Universidad Complutense de Madrid, Madrid, Spain; Hospital Universitario Virgen del Rocío, Seville, Spain. 4. Hospital Universitario Donostia, Donostia, Spain. 5. Hospital General Universitario Gregorio Marañón, Universidad Complutense de Madrid, Madrid, Spain. 6. Hospital Universitario Marqués de Valdecilla, Santander, Spain; Hospital Universitario Donostia, Donostia, Spain. 7. Hospital Universitario Cruces, Barakaldo, Spain. 8. Hospital Universitario Virgen de la Victoria, Málaga, Spain. 9. Hospital Universitario Virgen de la Macarena, Universidad de Sevilla, Seville, Spain. 10. Hospital Universitario Virgen de las Nieves, Granada, Spain. 11. Hospital Costa del Sol, Marbella, Spain. 12. Hospital Clínic de Barcelona, IDIBAPS, Universitat de Barcelona, Barcelona, Spain. Electronic address: jmmiro@ub.edu.
Abstract
OBJECTIVE: To investigate the rate of colorectal neoplasms (CRNs) in patients who have Enterococcus faecalis infective endocarditis (EFIE) with available colonoscopies and to assess whether this is associated with the identification of a focus the infection. PATIENTS AND METHODS: Retrospective analysis of data from a prospective multicenter study involving 35 centers who are members of the Grupo de Apoyo para el Manejo de la Endocarditis en España [Support Group for the Management of Infective Endocarditis in Spain] cohort. A specific set of queries regarding information on colonoscopy and histopathology of colorectal diseases was sent to each participating center. Four-hundred sixty-seven patients with EFIE were included from January 1, 2008, to December 31, 2017, from whom data on colonoscopy performance and results were available in 411 patients. RESULTS: One hundred forty-two (34.5%) patients had a colonoscopy close to the EFIE episode. The overall rate of colorectal diseases was 70.4% (100 of 142), whereas the prevalence of CRN (advanced adenomas and colorectal carcinoma) was 14.8% (21 of 142), with no significant differences between the group of EFIE of unknown focus and that with an identified focus. CONCLUSION: Our study adds to prior evidence suggesting a much higher rate of CRN among patients with EFIE than in the general population of the same age and sex. In addition, our findings suggest that this phenomenon might take place both in EFIE with an unknown and an identified source of infection.
OBJECTIVE: To investigate the rate of colorectal neoplasms (CRNs) in patients who have Enterococcus faecalis infective endocarditis (EFIE) with available colonoscopies and to assess whether this is associated with the identification of a focus the infection. PATIENTS AND METHODS: Retrospective analysis of data from a prospective multicenter study involving 35 centers who are members of the Grupo de Apoyo para el Manejo de la Endocarditis en España [Support Group for the Management of Infective Endocarditis in Spain] cohort. A specific set of queries regarding information on colonoscopy and histopathology of colorectal diseases was sent to each participating center. Four-hundred sixty-seven patients with EFIE were included from January 1, 2008, to December 31, 2017, from whom data on colonoscopy performance and results were available in 411 patients. RESULTS: One hundred forty-two (34.5%) patients had a colonoscopy close to the EFIE episode. The overall rate of colorectal diseases was 70.4% (100 of 142), whereas the prevalence of CRN (advanced adenomas and colorectal carcinoma) was 14.8% (21 of 142), with no significant differences between the group of EFIE of unknown focus and that with an identified focus. CONCLUSION: Our study adds to prior evidence suggesting a much higher rate of CRN among patients with EFIE than in the general population of the same age and sex. In addition, our findings suggest that this phenomenon might take place both in EFIE with an unknown and an identified source of infection.
Authors: Carlos Bea; Sara Vela; Sergio García-Blas; Jose-Angel Perez-Rivera; Pablo Díez-Villanueva; Ana Isabel de Gracia; Eladio Fuertes; Maria Rosa Oltra; Ana Ferrer; Andreu Belmonte; Enrique Santas; Mauricio Pellicer; Javier Colomina; Alberto Doménech; Vicente Bodi; Maria José Forner; Francisco Javier Chorro; Clara Bonanad Journal: J Cardiovasc Dev Dis Date: 2022-06-17
Authors: Eva Romay; Juan Manuel Pericàs; María José García-País; Marta Hernández-Meneses; Blanca Ayuso; Javier García-González; Rodrigo Vicente Garcés-Durán; Ramón Rabuñal; Pilar Alonso-García; Fernando García-Garrote; Andrés Perissinotti; Bàrbara Vidal; Carles Falces; Eduard Quintana; Leticia Moreira; Manel Almela; Josep Llach; Asunción Moreno; Juan Corredoira; Jose María Miró Journal: J Clin Med Date: 2022-04-13 Impact factor: 4.241