Literature DB >> 33413628

Brain monitoring using near-infrared spectroscopy to predict outcome after cardiac arrest: a novel phenotype in a rat model of cardiac arrest.

Ryosuke Takegawa1,2, Kei Hayashida3,4, Rishabh Choudhary1,2, Daniel M Rolston1,2, Lance B Becker1,2.   

Abstract

Improving neurological outcomes after cardiac arrest (CA) is the most important patient-oriented outcome for CA research. Near-infrared spectroscopy (NIRS) enables a non-invasive, real-time measurement of regional cerebral oxygen saturation. Here, we demonstrate a novel, non-invasive measurement using NIRS, termed modified cerebral oximetry index (mCOx), to distinguish the severity of brain injury after CA. We aimed to test the feasibility of this method to predict neurological outcome after asphyxial CA in rats. Our results suggest that mCOx is feasible shortly after resuscitation and can provide a surrogate measure for the severity of brain injury in a rat asphyxia CA model.

Entities:  

Keywords:  COx; Cardiac arrest; Cardiopulmonary resuscitation; Cerebral oximetry index; Cerebral oxygen saturation; NIRS; Near-infrared spectroscopy; Neurological outcome; Prognostication; rSO2

Year:  2021        PMID： 33413628      PMCID： PMC7787927          DOI： 10.1186/s40560-020-00521-9

Source DB:  PubMed          Journal:  J Intensive Care        ISSN： 2052-0492


  5 in total

1.  Are changes in cerebrovascular autoregulation following cardiac arrest associated with neurological outcome? Results of a pilot study.

Authors:  Paul Pham; Jessica Bindra; Alwin Chuan; Matthias Jaeger; Anders Aneman
Journal:  Resuscitation       Date:  2015-08-24       Impact factor: 5.262

2.  Study of the Effects of Epinephrine on Cerebral Oxygenation and Metabolism During Cardiac Arrest and Resuscitation by Hyperspectral Near-Infrared Spectroscopy.

Authors:  Reyhaneh Nosrati; Steve Lin; Rohit Mohindra; Andrew Ramadeen; Vladislav Toronov; Paul Dorian
Journal:  Crit Care Med       Date:  2019-04       Impact factor: 7.598

3.  Cerebral blood flow and cerebrovascular autoregulation in a swine model of pediatric cardiac arrest and hypothermia.

Authors:  Jennifer K Lee; Ken M Brady; Jennifer O Mytar; Kathleen K Kibler; Erin L Carter; Karen G Hirsch; Charles W Hogue; Ronald B Easley; Lori C Jordan; Peter Smielewski; Marek Czosnyka; Donald H Shaffner; Raymond C Koehler
Journal:  Crit Care Med       Date:  2011-10       Impact factor: 7.598

4.  An observational near-infrared spectroscopy study on cerebral autoregulation in post-cardiac arrest patients: time to drop 'one-size-fits-all' hemodynamic targets?

Authors:  K Ameloot; C Genbrugge; I Meex; F Jans; W Boer; M Vander Laenen; B Ferdinande; W Mullens; M Dupont; J Dens; C DeDeyne
Journal:  Resuscitation       Date:  2015-03-10       Impact factor: 5.262

5.  Using the relationship between brain tissue regional saturation of oxygen and mean arterial pressure to determine the optimal mean arterial pressure in patients following cardiac arrest: A pilot proof-of-concept study.

Authors:  Mypinder S Sekhon; Peter Smielewski; Tahara D Bhate; Penelope M Brasher; Denise Foster; David K Menon; Arun K Gupta; Marek Czosnyka; William R Henderson; Kenneth Gin; Graham Wong; Donald E Griesdale
Journal:  Resuscitation       Date:  2016-05-30       Impact factor: 5.262
  5 in total

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