BACKGROUND: Giant cell arteritis (GCA) is frequently associated with aortic involvement that is likely to cause life-threatening structural complications (aneurysm, dissection). Few studies have investigated the occurrence of these complications, and no predictive factor has been identified so far. The aim of this study was to investigate factors associated with the risk of aortic complications in a cohort of GCA aortitis. METHODS: Data of all patients managed with aortitis (CT or 18 FDG PET) at the diagnosis of GCA in five hospitals from May 1998 and April 2019 were retrospectively collected. Clinical features were compared according to the presence of aortitis symptoms. The predictive factors of occurrence or aggravation of aortic structural abnormalities were investigated. RESULTS: One hundred and seventy-one patients with GCA aortitis were included; 55 patients (32%) had symptoms of aortitis (dorsal/lumbar/abdominal pain, aortic insufficiency) at diagnosis. The median follow-up was 38 months. Aortic complications occurred after a median time of 32 months. There were 19 new aortic aneurysms or complications of aneurysm and 5 dissections. Survival without aortic complication was significantly different between the symptomatic and non-symptomatic groups (Log rank, p = 0.0003). In multivariate analysis the presence of aortitis symptoms at diagnosis (HR 6.64 [1.95, 22.6] p = 0.002) and GCA relapse (HR 3.62 [1.2, 10.9] p = 0.02) were factors associated with the occurrence of aortic complications. CONCLUSION: In this study, the presence of aortitis symptoms at the diagnosis of GCA aortitis and GCA relapse were independent predictive factors of occurrence of aortic complications during follow-up.
BACKGROUND:Giant cell arteritis (GCA) is frequently associated with aortic involvement that is likely to cause life-threatening structural complications (aneurysm, dissection). Few studies have investigated the occurrence of these complications, and no predictive factor has been identified so far. The aim of this study was to investigate factors associated with the risk of aortic complications in a cohort of GCA aortitis. METHODS: Data of all patients managed with aortitis (CT or 18 FDG PET) at the diagnosis of GCA in five hospitals from May 1998 and April 2019 were retrospectively collected. Clinical features were compared according to the presence of aortitis symptoms. The predictive factors of occurrence or aggravation of aortic structural abnormalities were investigated. RESULTS: One hundred and seventy-one patients with GCA aortitis were included; 55 patients (32%) had symptoms of aortitis (dorsal/lumbar/abdominal pain, aortic insufficiency) at diagnosis. The median follow-up was 38 months. Aortic complications occurred after a median time of 32 months. There were 19 new aortic aneurysms or complications of aneurysm and 5 dissections. Survival without aortic complication was significantly different between the symptomatic and non-symptomatic groups (Log rank, p = 0.0003). In multivariate analysis the presence of aortitis symptoms at diagnosis (HR 6.64 [1.95, 22.6] p = 0.002) and GCA relapse (HR 3.62 [1.2, 10.9] p = 0.02) were factors associated with the occurrence of aortic complications. CONCLUSION: In this study, the presence of aortitis symptoms at the diagnosis of GCA aortitis and GCA relapse were independent predictive factors of occurrence of aortic complications during follow-up.
Authors: Luciana Martinez-Lado; Carolina Calviño-Díaz; Angela Piñeiro; Trinidad Dierssen; Tomas R Vazquez-Rodriguez; Jose A Miranda-Filloy; Maria J Lopez-Diaz; Ricardo Blanco; Javier Llorca; Miguel A Gonzalez-Gay Journal: Medicine (Baltimore) Date: 2011-05 Impact factor: 1.889
Authors: Tanaz A Kermani; Kenneth J Warrington; David Cuthbertson; Simon Carette; Gary S Hoffman; Nader A Khalidi; Curry L Koening; Carol A Langford; Kathleen Maksimowicz-McKinnon; Carol A McAlear; Paul A Monach; Philip Seo; Peter A Merkel; Steven R Ytterberg Journal: J Rheumatol Date: 2015-04-15 Impact factor: 4.666
Authors: Hubert de Boysson; Aurélie Daumas; Mathieu Vautier; Jean-Jacques Parienti; Eric Liozon; Marc Lambert; Maxime Samson; Mikael Ebbo; Anael Dumont; Audrey Sultan; Bernard Bonnotte; Alain Manrique; Boris Bienvenu; David Saadoun; Achille Aouba Journal: Autoimmun Rev Date: 2018-02-07 Impact factor: 9.754
Authors: Miguel A Gonzalez-Gay; Carlos Garcia-Porrua; Angela Piñeiro; Robustiano Pego-Reigosa; Javier Llorca; Gene G Hunder Journal: Medicine (Baltimore) Date: 2004-11 Impact factor: 1.889
Authors: B Bienvenu; K H Ly; M Lambert; C Agard; M André; Y Benhamou; B Bonnotte; H de Boysson; O Espitia; G Fau; A-L Fauchais; F Galateau-Sallé; J Haroche; E Héron; F-X Lapébie; E Liozon; L B Luong Nguyen; J Magnant; A Manrique; M Matt; M de Menthon; L Mouthon; X Puéchal; G Pugnet; T Quemeneur; A Régent; D Saadoun; M Samson; D Sène; P Smets; C Yelnik; L Sailler; A Mahr Journal: Rev Med Interne Date: 2016-01-29 Impact factor: 0.728
Authors: Marco A Alba; Ana García-Martínez; Sergio Prieto-González; Itziar Tavera-Bahillo; Marc Corbera-Bellalta; Ester Planas-Rigol; Georgina Espígol-Frigolé; Montserrat Butjosa; José Hernández-Rodríguez; Maria C Cid Journal: Medicine (Baltimore) Date: 2014-07 Impact factor: 1.889
Authors: Mehrnam Amouei; Sara Momtazmanesh; Hoda Kavosi; Amir H Davarpanah; Ali Shirkhoda; Amir Reza Radmard Journal: Insights Imaging Date: 2022-09-04