Si-Ying Song1,2,3, Gary Rajah3,4, Yu-Chuan Ding3,5, Xun-Ming Ji2,3, Ran Meng6,7,8. 1. Department of Neurology, Xuanwu Hospital, Capital Medical University, Chang Chun road 45, Xicheng, Beijing, China. 2. Advanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing, 100053, China. 3. Department of China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China. 4. Department of Neurosurgery, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA. 5. Department of Neurosurgery, Wayne State University School of Medicine, Detroit, MI, 48201, USA. 6. Department of Neurology, Xuanwu Hospital, Capital Medical University, Chang Chun road 45, Xicheng, Beijing, China. victor65@126.com. 7. Advanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing, 100053, China. victor65@126.com. 8. Department of China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China. victor65@126.com.
Abstract
BACKGROUND: Antiphospholipid syndrome (APS) is associated with a high incidence of thrombotic events, either arterial thrombosis or venous thrombosis. However, APS-related non-thrombotic venous stenosis is rarely reported. CASE PRESENTATION: This study described two cases of young women with APS-related internal jugular vein stenosis (IJVS) and reviewed current literature on this issue, including clinical features, diagnosis, and treatment. CONCLUSIONS: IJVS is a rather rare complication of APS. Two cases were reported for the first time that high titer of antiphospholipid antibodies (aPL) might mediate direct vessel wall damage and further induce venous stenosis despite long-term standardized anticoagulation to prevent thrombus formation. Therefore, dynamic monitoring of autoantibodies and concomitant use of anticoagulants and corticosteroids may be necessary to the management of APS and its complications.
BACKGROUND:Antiphospholipid syndrome (APS) is associated with a high incidence of thrombotic events, either arterial thrombosis or venous thrombosis. However, APS-related non-thrombotic venous stenosis is rarely reported. CASE PRESENTATION: This study described two cases of young women with APS-related internal jugular vein stenosis (IJVS) and reviewed current literature on this issue, including clinical features, diagnosis, and treatment. CONCLUSIONS: IJVS is a rather rare complication of APS. Two cases were reported for the first time that high titer of antiphospholipid antibodies (aPL) might mediate direct vessel wall damage and further induce venous stenosis despite long-term standardized anticoagulation to prevent thrombus formation. Therefore, dynamic monitoring of autoantibodies and concomitant use of anticoagulants and corticosteroids may be necessary to the management of APS and its complications.
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