Hyun Lee1, Sang-Heon Kim1, Byung-Keun Kim2, Youngsoo Lee3, Hwa Young Lee4, Ga-Young Ban5, Min-Hye Kim6, Joo-Hee Kim7, Jae-Woo Kwon8, So-Young Park9, Jae-Woo Jung10, So Young Park11, Chan Sun Park12, Chin Kook Rhee4, Taehoon Lee13, Jae-Hyun Lee14, So Ri Kim15, Jong-Sook Park16, Heung-Woo Park17, Kwang Ha Yoo9, Yeon-Mok Oh18, Young-Il Koh19, Byung-Jae Lee20, An-Soo Jang16, Sang-Heon Cho17, Hae-Sim Park3, Choon-Sik Park16, You Sook Cho18, Ho Joo Yoon1. 1. Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea. 2. Department of Internal Medicine, Korea University Medical Center Anam Hospital, Seoul, Korea. 3. Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea. 4. Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Seoul St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. 5. Department of Pulmonary, Allergy and Critical Care Medicine, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea. 6. Department of Internal Medicine, College of Medicine, Ewha Womans University, Seoul, Korea. 7. Department of Internal Medicine, Hallym University College of Medicine, Anyang, Korea. 8. Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon, Korea. 9. Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea. 10. Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea. 11. Department of Internal Medicine, Eulji University School of Medicine, Seoul, Korea. 12. Department of Internal Medicine, Inje University, Haeundae Paik Hospital, Busan, Korea. 13. Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea. 14. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. 15. Division of Respiratory Medicine and Allergy, Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Korea. 16. Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon, Korea. 17. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. 18. Department of Internal Medicine, University of Ulsan College of Medicine, Seoul, Korea. 19. Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea. 20. Department of Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea.
Abstract
BACKGROUND: While the clinical characteristics and outcomes of asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) have been frequently compared with those of COPD or asthma, the prevalence and features of ACO in patients with severe asthma are unclear. OBJECTIVES: Evaluation of the prevalence and clinical features of ACO using the Korean severe asthma registry. METHODS: At the time of registration, ACO was determined in patients with severe asthma by attending specialists. Patients were classified into ACO and non-ACO groups, and the demographic and clinical characteristics of these two groups were compared. RESULTS: Of 482 patients with severe asthma, 23.7% had ACO. Patients in the ACO group were more likely to be male (P < .001), older (P < .001), and ex- or current smokers (P < .001) compared with those in the non-ACO group. Patients in the ACO group had lower mean forced expiratory volume in 1 second (P < .001) and blood eosinophil percentage (P = .006), but higher blood neutrophil percentage (P = .027) than those in the non-ACO group. The ACO group used more inhaled long-acting muscarinic antagonist (P < .001), methylxanthine (P = .001), or sustained systemic corticosteroid (P = .002). In addition, unscheduled emergency department visits due to exacerbation were more frequent in the ACO group (P = .006). CONCLUSION: Among patients with severe asthma, those with ACO were older, predominantly male, and were more likely to have a smoking history than those with asthma only. Patients with ACO used more systemic corticosteroid and had more frequent exacerbations related to emergency department visits than those with severe asthma only.
BACKGROUND: While the clinical characteristics and outcomes of asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) have been frequently compared with those of COPD or asthma, the prevalence and features of ACO in patients with severe asthma are unclear. OBJECTIVES: Evaluation of the prevalence and clinical features of ACO using the Korean severe asthma registry. METHODS: At the time of registration, ACO was determined in patients with severe asthma by attending specialists. Patients were classified into ACO and non-ACO groups, and the demographic and clinical characteristics of these two groups were compared. RESULTS: Of 482 patients with severe asthma, 23.7% had ACO. Patients in the ACO group were more likely to be male (P < .001), older (P < .001), and ex- or current smokers (P < .001) compared with those in the non-ACO group. Patients in the ACO group had lower mean forced expiratory volume in 1 second (P < .001) and blood eosinophil percentage (P = .006), but higher blood neutrophil percentage (P = .027) than those in the non-ACO group. The ACO group used more inhaled long-acting muscarinic antagonist (P < .001), methylxanthine (P = .001), or sustained systemic corticosteroid (P = .002). In addition, unscheduled emergency department visits due to exacerbation were more frequent in the ACO group (P = .006). CONCLUSION: Among patients with severe asthma, those with ACO were older, predominantly male, and were more likely to have a smoking history than those with asthma only. Patients with ACO used more systemic corticosteroid and had more frequent exacerbations related to emergency department visits than those with severe asthma only.
Authors: Ji-Hyang Lee; Hyo-Jung Kim; Chan Sun Park; So Young Park; So-Young Park; Hyun Lee; Sang-Heon Kim; You Sook Cho Journal: Allergy Asthma Immunol Res Date: 2022-07 Impact factor: 5.096
Authors: Hyonsoo Joo; So-Young Park; So Young Park; Seo Young Park; Sang-Heon Kim; You Sook Cho; Kwang Ha Yoo; Ki Suck Jung; Chin Kook Rhee Journal: J Korean Med Sci Date: 2022-08-01 Impact factor: 5.354