Literature DB >> 33411079

The regulation of the small-conductance calcium-activated potassium current and the mechanisms of sex dimorphism in J wave syndrome.

Mu Chen1, Yudong Fei1, Tai-Zhong Chen1, Yi-Gang Li1, Peng-Sheng Chen2.   

Abstract

Apamin-sensitive small-conductance calcium-activated potassium (SK) current (IKAS) plays an important role in cardiac repolarization under a variety of physiological and pathological conditions. The regulation of cardiac IKAS relies on SK channel expression, intracellular Ca2+, and interaction between SK channel and intracellular Ca2+. IKAS activation participates in multiple types of arrhythmias, including atrial fibrillation, ventricular tachyarrhythmias, and automaticity and conduction abnormality. Recently, sex dimorphisms in autonomic control have been noticed in IKAS activation, resulting in sex-differentiated action potential morphology and arrhythmogenesis. This review provides an update on the Ca2+-dependent regulation of cardiac IKAS and the role of IKAS on arrhythmias, with a special focus on sex differences in IKAS activation. We propose that sex dimorphism in autonomic control of IKAS may play a role in J wave syndrome.

Entities:  

Keywords:  Autonomic control; Brugada syndrome; Early repolarization; Ion channel; J wave syndrome; Sex difference; Sex dimorphism

Mesh：

Substances：

Year:  2021        PMID： 33411079      PMCID： PMC8855337          DOI： 10.1007/s00424-020-02500-3

Source DB:  PubMed          Journal:  Pflugers Arch        ISSN： 0031-6768            Impact factor:   3.657


  114 in total

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Authors:  Dipika Tuteja; Sassan Rafizadeh; Valeriy Timofeyev; Shuyun Wang; Zheng Zhang; Ning Li; Robertino K Mateo; Anil Singapuri; J Nilas Young; Anne A Knowlton; Nipavan Chiamvimonvat
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2.  The Use of Noninvasive Vagal Nerve Stimulation to Inhibit Sympathetically Induced Sinus Node Acceleration: A Potential Therapeutic Approach for Inappropriate Sinus Tachycardia.

Authors:  Xiaoya Zhou; Liping Zhou; Songyun Wang; Lilei Yu; Zhuo Wang; Bing Huang; Mingxian Chen; Jun Wan; Hong Jiang
Journal:  J Cardiovasc Electrophysiol       Date:  2015-11-23

3.  Sarcoplasmic reticulum Ca²⁺ release is both necessary and sufficient for SK channel activation in ventricular myocytes.

Authors:  Dmitry Terentyev; Jennifer A Rochira; Radmila Terentyeva; Karim Roder; Gideon Koren; Weiyan Li
Journal:  Am J Physiol Heart Circ Physiol       Date:  2013-12-31       Impact factor: 4.733

4.  Distinct subcellular mechanisms for the enhancement of the surface membrane expression of SK2 channel by its interacting proteins, α-actinin2 and filamin A.

Authors:  Zheng Zhang; Hannah A Ledford; Seojin Park; Wenying Wang; Sassan Rafizadeh; Hyo Jeong Kim; Wilson Xu; Ling Lu; Victor C Lau; Anne A Knowlton; Xiao-Dong Zhang; Ebenezer N Yamoah; Nipavan Chiamvimonvat
Journal:  J Physiol       Date:  2016-12-07       Impact factor: 5.182

5.  Regulation of gene transcription by voltage-gated L-type calcium channel, Cav1.3.

Authors:  Ling Lu; Padmini Sirish; Zheng Zhang; Ryan L Woltz; Ning Li; Valeriy Timofeyev; Anne A Knowlton; Xiao-Dong Zhang; Ebenezer N Yamoah; Nipavan Chiamvimonvat
Journal:  J Biol Chem       Date:  2014-12-23       Impact factor: 5.157

6.  Cellular basis of sex disparities in human cardiac electrophysiology.

Authors:  A O Verkerk; R Wilders; W de Geringel; H L Tan
Journal:  Acta Physiol (Oxf)       Date:  2006-08       Impact factor: 6.311

7.  Role of small-conductance calcium-activated potassium channels in atrial electrophysiology and fibrillation in the dog.

Authors:  Xiao-Yan Qi; Jonas G Diness; Bianca J J M Brundel; Xiao-Bo Zhou; Patrice Naud; Chia-Tung Wu; Hai Huang; Masahide Harada; Mona Aflaki; Dobromir Dobrev; Morten Grunnet; Stanley Nattel
Journal:  Circulation       Date:  2013-11-04       Impact factor: 29.690

8.  Protection against cardiac injury by small Ca(2+)-sensitive K(+) channels identified in guinea pig cardiac inner mitochondrial membrane.

Authors:  David F Stowe; Ashish K Gadicherla; Yifan Zhou; Mohammed Aldakkak; Qunli Cheng; Wai-Meng Kwok; Ming Tao Jiang; James S Heisner; Meiying Yang; Amadou K S Camara
Journal:  Biochim Biophys Acta       Date:  2012-09-08

9.  Microdomain-Specific Modulation of L-Type Calcium Channels Leads to Triggered Ventricular Arrhythmia in Heart Failure.

Authors:  Jose L Sanchez-Alonso; Anamika Bhargava; Thomas O'Hara; Alexey V Glukhov; Sophie Schobesberger; Navneet Bhogal; Markus B Sikkel; Catherine Mansfield; Yuri E Korchev; Alexander R Lyon; Prakash P Punjabi; Viacheslav O Nikolaev; Natalia A Trayanova; Julia Gorelik
Journal:  Circ Res       Date:  2016-08-29       Impact factor: 17.367

10.  The KCa2 Channel Inhibitor AP30663 Selectively Increases Atrial Refractoriness, Converts Vernakalant-Resistant Atrial Fibrillation and Prevents Its Reinduction in Conscious Pigs.

Authors:  Jonas Goldin Diness; Jeppe Egedal Kirchhoff; Tobias Speerschneider; Lea Abildgaard; Nils Edvardsson; Ulrik S Sørensen; Morten Grunnet; Bo Hjorth Bentzen
Journal:  Front Pharmacol       Date:  2020-02-28       Impact factor: 5.810
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  2 in total

1.  Why Is Only Type 1 Electrocardiogram Diagnostic of Brugada Syndrome? Mechanistic Insights From Computer Modeling.

Authors:  Zhaoyang Zhang; Peng-Sheng Chen; James N Weiss; Zhilin Qu
Journal:  Circ Arrhythm Electrophysiol       Date:  2021-12-29

2.  Lack of UBE3A-Mediated Regulation of Synaptic SK2 Channels Contributes to Learning and Memory Impairment in the Female Mouse Model of Angelman Syndrome.

Authors:  Jiandong Sun; Yan Liu; Xiaoning Hao; Michel Baudry; Xiaoning Bi
Journal:  Neural Plast       Date:  2022-10-04       Impact factor: 3.144
  2 in total

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