Literature DB >> 3341048

Alterations in the thyroids of rats treated for long periods with di-(2-ethylhexyl) phthalate or with hypolipidaemic agents.

S C Price1, D Chescoe, P Grasso, M Wright, R H Hinton.   

Abstract

Treatment of rats for periods of 3 months or longer with the hypolipidaemic drugs clofibrate and fenofibrate or with the plasticiser di-(2-ethylhexyl) phthalate causes alterations in the thyroid. The colloid is shrunken and contains calcium-rich inclusions. Electron microscopy shows increases in the number and size of lysosomes, hypertrophy of the Golgi apparatus and dilation of the rough endoplasmic reticulum. These changes are consistent with persistent hyperactivity in the gland.

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Year:  1988        PMID： 3341048     DOI： 10.1016/0378-4274(88)90181-6

Source DB:  PubMed          Journal:  Toxicol Lett        ISSN： 0378-4274            Impact factor:   4.372


  19 in total

1.  A cross sectional study of urinary phthalates, phenols and perchlorate on thyroid hormones in US adults using structural equation models (NHANES 2007-2008).

Authors:  Jennifer Przybyla; G John Geldhof; Ellen Smit; Molly L Kile
Journal:  Environ Res       Date:  2018-02-06       Impact factor: 6.498

Review 2.  Nonproliferative and Proliferative Lesions of the Rat and Mouse Endocrine System.

Authors:  Annamaria Brändli-Baiocco; Emmanuelle Balme; Marc Bruder; Sundeep Chandra; Juergen Hellmann; Mark J Hoenerhoff; Takahito Kambara; Christian Landes; Barbara Lenz; Mark Mense; Susanne Rittinghausen; Hiroshi Satoh; Frédéric Schorsch; Frank Seeliger; Takuji Tanaka; Minoru Tsuchitani; Zbigniew Wojcinski; Thomas J Rosol
Journal:  J Toxicol Pathol       Date:  2018-07-28       Impact factor: 1.628

3.  Prenatal phthalate exposure and performance on the Neonatal Behavioral Assessment Scale in a multiethnic birth cohort.

Authors:  Stephanie M Engel; Chenbo Zhu; Gertrud S Berkowitz; Antonia M Calafat; Manori J Silva; Amir Miodovnik; Mary S Wolff
Journal:  Neurotoxicology       Date:  2009-04-16       Impact factor: 4.294

4.  Characterization of peroxisome proliferator-activated receptor alpha--independent effects of PPARalpha activators in the rodent liver: di-(2-ethylhexyl) phthalate also activates the constitutive-activated receptor.

Authors:  Hongzu Ren; Lauren M Aleksunes; Carmen Wood; Beena Vallanat; Michael H George; Curtis D Klaassen; J Christopher Corton
Journal:  Toxicol Sci       Date:  2009-10-22       Impact factor: 4.849

5.  Association between phthalates and attention deficit disorder and learning disability in U.S. children, 6-15 years.

Authors:  Vidita Chopra; Kim Harley; Maureen Lahiff; Brenda Eskenazi
Journal:  Environ Res       Date:  2013-11-19       Impact factor: 6.498

6.  Relationship between urinary phthalate and bisphenol A concentrations and serum thyroid measures in U.S. adults and adolescents from the National Health and Nutrition Examination Survey (NHANES) 2007-2008.

Authors:  John D Meeker; Kelly K Ferguson
Journal:  Environ Health Perspect       Date:  2011-07-11       Impact factor: 9.031

7.  Maternal prenatal urinary phthalate metabolite concentrations and child mental, psychomotor, and behavioral development at 3 years of age.

Authors:  Robin M Whyatt; Xinhua Liu; Virginia A Rauh; Antonia M Calafat; Allan C Just; Lori Hoepner; Diurka Diaz; James Quinn; Jennifer Adibi; Frederica P Perera; Pam Factor-Litvak
Journal:  Environ Health Perspect       Date:  2011-09-06       Impact factor: 9.031

8.  Prenatal phthalate exposure is associated with childhood behavior and executive functioning.

Authors:  Stephanie M Engel; Amir Miodovnik; Richard L Canfield; Chenbo Zhu; Manori J Silva; Antonia M Calafat; Mary S Wolff
Journal:  Environ Health Perspect       Date:  2010-01-08       Impact factor: 9.031

Review 9.  Neurodevelopment and endocrine disruption.

Authors:  Theo Colborn
Journal:  Environ Health Perspect       Date:  2004-06       Impact factor: 9.031

10.  Di(2-ethylhexyl) phthalate metabolites may alter thyroid hormone levels in men.

Authors:  John D Meeker; Antonia M Calafat; Russ Hauser
Journal:  Environ Health Perspect       Date:  2007-07       Impact factor: 9.031
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