| Literature DB >> 33408181 |
Jennifer M Dan1,2, Jose Mateus1, Yu Kato1, Kathryn M Hastie1, Esther Dawen Yu1, Caterina E Faliti1, Alba Grifoni1, Sydney I Ramirez1,2, Sonya Haupt1, April Frazier1, Catherine Nakao1, Vamseedhar Rayaprolu1, Stephen A Rawlings2, Bjoern Peters1,3, Florian Krammer4, Viviana Simon4,5,6, Erica Ollmann Saphire1,2, Davey M Smith2, Daniela Weiskopf7, Alessandro Sette7,2, Shane Crotty7,2.
Abstract
Understanding immune memory to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical for improving diagnostics and vaccines and for assessing the likely future course of the COVID-19 pandemic. We analyzed multiple compartments of circulating immune memory to SARS-CoV-2 in 254 samples from 188 COVID-19 cases, including 43 samples at ≥6 months after infection. Immunoglobulin G (IgG) to the spike protein was relatively stable over 6+ months. Spike-specific memory B cells were more abundant at 6 months than at 1 month after symptom onset. SARS-CoV-2-specific CD4+ T cells and CD8+ T cells declined with a half-life of 3 to 5 months. By studying antibody, memory B cell, CD4+ T cell, and CD8+ T cell memory to SARS-CoV-2 in an integrated manner, we observed that each component of SARS-CoV-2 immune memory exhibited distinct kinetics.Entities:
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Year: 2021 PMID： 33408181 PMCID： PMC7919858 DOI： 10.1126/science.abf4063
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728