Hugo Carrillo-Ng1,2, Lorena Becerra-Goicochea3, Yordi Tarazona-Castro2,4, Luis Pinillos-Vilca3, Luis J Del Valle5, Miguel Angel Aguilar-Luis1,2, Carmen Tinco-Valdez1,2, Wilmer Silva-Caso6,7, Johanna Martins-Luna1,2, Isaac Peña-Tuesta1,2, Ronald Aquino-Ortega1,2, Juana Del Valle-Mendoza8,9. 1. School of Medicine, Research and Innovation Center of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Av. San Marcos Cuadra 2, Chorrillos, Lima, Peru. 2. Laboratorio de Biologia Molecular, Instituto de Investigación Nutricional, Lima, Peru. 3. Hospital Regional Docente de Cajamarca, Cajamarca, Peru. 4. Escuela Profesional de Genética y Biotecnología, Facultad de Ciencias Biológicas, Universidad Nacional Mayor de San Marcos, Lima, Peru. 5. Departament d'Enginyeria Química, EEBE, Barcelona Research Center for Multiscale Science and Engineering, Universitat Politècnica de Catalunya (UPC), Barcelona, Spain. 6. School of Medicine, Research and Innovation Center of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Av. San Marcos Cuadra 2, Chorrillos, Lima, Peru. gian_will@hotmail.com. 7. Laboratorio de Biologia Molecular, Instituto de Investigación Nutricional, Lima, Peru. gian_will@hotmail.com. 8. School of Medicine, Research and Innovation Center of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Av. San Marcos Cuadra 2, Chorrillos, Lima, Peru. juana.delvalle@upc.pe. 9. Laboratorio de Biologia Molecular, Instituto de Investigación Nutricional, Lima, Peru. juana.delvalle@upc.pe.
Abstract
OBJECTIVE: To characterize the cervicovaginal microbiota of HPV-positive and HPV-negative asymptomatic Peruvian women, by identifying the presence of 13 representative bacteria genus. RESULTS: A total of 100 HPV-positive and 100 HPV-negative women were matched by age for comparison of microbiota. The following bacteria were more frequently identified in HPV-positive patients compared to HPV-negative: Eubacterium (68 vs 32%), Actinobacteria (46 vs 33%), Fusobacterium (11 vs 6%) and Bacteroides (20 vs 13%). A comparison between high-risk and low-risk genotypes was performed and differences were found in the detection of Actinobacteria (50 vs 33.33%), Bifidobacterium (50 vs 20.83%) and Enterococcus (50 vs 29.17%).
OBJECTIVE: To characterize the cervicovaginal microbiota of HPV-positive and HPV-negative asymptomatic Peruvian women, by identifying the presence of 13 representative bacteria genus. RESULTS: A total of 100 HPV-positive and 100 HPV-negative women were matched by age for comparison of microbiota. The following bacteria were more frequently identified in HPV-positive patients compared to HPV-negative: Eubacterium (68 vs 32%), Actinobacteria (46 vs 33%), Fusobacterium (11 vs 6%) and Bacteroides (20 vs 13%). A comparison between high-risk and low-risk genotypes was performed and differences were found in the detection of Actinobacteria (50 vs 33.33%), Bifidobacterium (50 vs 20.83%) and Enterococcus (50 vs 29.17%).
Entities:
Keywords:
Cervical cancer; HPV; Human papillomavirus; Microbiota; PCR; Peru
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