Hamed Gheibollahi1, Amirreza Dehghanian2,3, Negar Taheri4, Saeid Tavanafar5, Seyede Sona Mousavi1, Hamidreza Abbasi6, Mohammadreza Sasani7. 1. Oral and Maxillofacial Surgery, Department of Oral and Maxillofacial Surgery, Shiraz University of Medical Sciences, Shiraz, Iran. 2. Surgical and Clinical Pathology, Trauma Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. 3. Molecular Pathology and Cytogenetics Ward, Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran. 4. Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran. 5. Oral and Maxillofacial Surgery, Department of Oral and Maxillofacial Surgery, Shiraz University of Medical Sciences, Shiraz, Iran. s.tavanafar@gmail.com. 6. Trauma Research Center, Shahid Rajaee (Emtiaz) Trauma Hospital, Shiraz University of Medical Sciences, Shiraz, Iran. 7. Department of Radiology, Medical Imaging Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Abstract
BACKGROUND: Esophageal leiomyosarcoma (LMS) is a rare tumor that constitutes less than 1% of all malignant esophageal tumors. Concurrent occurrence of esophageal leiomyosarcoma with squamous cell carcinoma (SCC) is even rarer than isolated leiomyosarcoma. CASE PRESENTATION: In this report, we present a case of concurrent leiomyosarcoma and SCC in a 64-year-old woman presenting with vomiting and solid dysphagia, which has not been properly diagnosed following several referrals and diagnostic modalities. At last Exploratory laparotomy with gastric pull-up was performed in addition to radical laryngectomy with partial resection of the esophagus and subtotal thyroidectomy. Pathologic evaluation of the surgical specimen showed concurrent LMS (5.2 × 4.5 × 3 cm) and SCC (1.5 × 0.6 × 0.6 cm) at the same anatomical level in the proximal esophagus. CONCLUSIONS: This study proposes the importance of using ancillary diagnostic tests such as immunohistochemistry (IHC) to diagnose less common cases such as concurrent LMS and SCC.
BACKGROUND:Esophageal leiomyosarcoma (LMS) is a rare tumor that constitutes less than 1% of all malignant esophageal tumors. Concurrent occurrence of esophageal leiomyosarcoma with squamous cell carcinoma (SCC) is even rarer than isolated leiomyosarcoma. CASE PRESENTATION: In this report, we present a case of concurrent leiomyosarcoma and SCC in a 64-year-old woman presenting with vomiting and solid dysphagia, which has not been properly diagnosed following several referrals and diagnostic modalities. At last Exploratory laparotomy with gastric pull-up was performed in addition to radical laryngectomy with partial resection of the esophagus and subtotal thyroidectomy. Pathologic evaluation of the surgical specimen showed concurrent LMS (5.2 × 4.5 × 3 cm) and SCC (1.5 × 0.6 × 0.6 cm) at the same anatomical level in the proximal esophagus. CONCLUSIONS: This study proposes the importance of using ancillary diagnostic tests such as immunohistochemistry (IHC) to diagnose less common cases such as concurrent LMS and SCC.
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