Midori Doke1, Yuriko Komagamine2, Manabu Kanazawa1, Maiko Iwaki3, Hiroyuki Suzuki1, Yasunari Miyazaki4, Tetsuya Mizuno5, Kaori Okayasu6, Shunsuke Minakuchi1. 1. Gerodontology and Oral Rehabilitation, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Yushima, Bunkyo-ku, Tokyo, Japan. 2. Gerodontology and Oral Rehabilitation, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Yushima, Bunkyo-ku, Tokyo, Japan. y.komagamine.gerd@tmd.ac.jp. 3. General Dentistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan. 4. Department of Respiratory Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan. 5. Department of Health Science and Physical Education, College of Liberal Arts and Sciences, Tokyo Medical and Dental University, Tokyo, Japan. 6. Yokohama City Minato Red Cross Hospital Medical Center for Allergic and Immune Diseases, Yokohama, Japan.
Abstract
BACKGROUND:Metabolic syndrome (MetS), caused by the accumulation of visceral fat, is considered a major cause of cardiovascular disease. This randomized controlled trial aimed to clarify the effect of dental intervention, including prosthodontics and/or periodontal treatment, combined with dietary and exercise guidance on MetS. METHODS: In total, 112 patients who met the Japanese waist circumference criteria of MetS were recruited. The intervention group (ITG) received dental intervention along with dietary and exercise guidance, while the control group (CTG) received dietary and exercise guidance alone. Three outcome measurements were obtained before intervention (BL), 1 month after intervention (1M), and 3 months after intervention (3M). RESULTS:Body water rate (p = 0.043) was significantly higher in ITG than in CTG at 1M. Simultaneously, fasting blood sugar level (p = 0.098) tended to be lower in ITG than in CTG. Lean mass (p = 0.037) and muscle mass (p = 0.035) were significantly higher and body weight (p = 0.044) significantly lower in ITG than in CTG at 3M. Body mass index (p = 0.052) tended to be lower in ITG than in CTG. CONCLUSIONS:Dental intervention combined with lifestyle guidance may improve anthropometric status and reduce the risk of MetS. TRIAL REGISTRATION: University Hospital Medical Information Network Center Unique UMIN000022753. https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000026176 .
RCT Entities:
BACKGROUND:Metabolic syndrome (MetS), caused by the accumulation of visceral fat, is considered a major cause of cardiovascular disease. This randomized controlled trial aimed to clarify the effect of dental intervention, including prosthodontics and/or periodontal treatment, combined with dietary and exercise guidance on MetS. METHODS: In total, 112 patients who met the Japanese waist circumference criteria of MetS were recruited. The intervention group (ITG) received dental intervention along with dietary and exercise guidance, while the control group (CTG) received dietary and exercise guidance alone. Three outcome measurements were obtained before intervention (BL), 1 month after intervention (1M), and 3 months after intervention (3M). RESULTS: Body water rate (p = 0.043) was significantly higher in ITG than in CTG at 1M. Simultaneously, fasting blood sugar level (p = 0.098) tended to be lower in ITG than in CTG. Lean mass (p = 0.037) and muscle mass (p = 0.035) were significantly higher and body weight (p = 0.044) significantly lower in ITG than in CTG at 3M. Body mass index (p = 0.052) tended to be lower in ITG than in CTG. CONCLUSIONS: Dental intervention combined with lifestyle guidance may improve anthropometric status and reduce the risk of MetS. TRIAL REGISTRATION: University Hospital Medical Information Network Center Unique UMIN000022753. https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000026176 .
Authors: Yukiko Hatanaka; Junichi Furuya; Yuji Sato; Risako Taue; Yoshiki Uchida; Toshiharu Shichita; Tokiko Osawa Journal: Int J Environ Res Public Health Date: 2022-02-14 Impact factor: 3.390