Pablo A Rojas1, Cristián González2, Gonzalo P Mendez3, Alejandro Majerson1, Ignacio F San Francisco4. 1. Departamento de Urología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Diagonal Paraguay 362, Santiago, Chile. 2. División de Ginecología y Obstetricia, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. 3. Departamento de Anatomía-Patológica, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. 4. Departamento de Urología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Diagonal Paraguay 362, Santiago, Chile. isanfrancisco@med.puc.cl.
Abstract
BACKGROUND: Bladder tumors in pregnancy are extremely rare. No more than 50 cases have been published to date, including all histologic variants, and only three cases of bladder squamous cell carcinoma have been described. CASE PRESENTATION: We present a clinical case of a 31-year-old woman with bladder squamous cell carcinoma in the second trimester of pregnancy. After a C-section at 30 weeks, we performed radical cystectomy with extended bilateral lymphadenectomy, hysterectomy and right oophorectomy. The Studer neobladder technique was performed for urinary tract reconstruction. Definitive pathology showed invasive bladder squamous cell carcinoma, Grade 2, with microscopic infiltration of the perivesical fat, negative margins, and 3/28 lymph nodes with carcinoma (pT3aN2M0). The patient underwent 18 months of surveillance after radical cystectomy, without recurrence by PET-CT. CONCLUSIONS: Bladder cancer in pregnant women is extremely rare but must be considered in those with recurrent gross hematuria and/or recurrent urinary tract infection. To our knowledge, this case involves the longest recurrence-free survival of a pregnant woman with squamous cell bladder cancer published thus far.
BACKGROUND:Bladder tumors in pregnancy are extremely rare. No more than 50 cases have been published to date, including all histologic variants, and only three cases of bladder squamous cell carcinoma have been described. CASE PRESENTATION: We present a clinical case of a 31-year-old woman with bladder squamous cell carcinoma in the second trimester of pregnancy. After a C-section at 30 weeks, we performed radical cystectomy with extended bilateral lymphadenectomy, hysterectomy and right oophorectomy. The Studer neobladder technique was performed for urinary tract reconstruction. Definitive pathology showed invasive bladder squamous cell carcinoma, Grade 2, with microscopic infiltration of the perivesical fat, negative margins, and 3/28 lymph nodes with carcinoma (pT3aN2M0). The patient underwent 18 months of surveillance after radical cystectomy, without recurrence by PET-CT. CONCLUSIONS:Bladder cancer in pregnant women is extremely rare but must be considered in those with recurrent gross hematuria and/or recurrent urinary tract infection. To our knowledge, this case involves the longest recurrence-free survival of a pregnant woman with squamous cell bladder cancer published thus far.
Entities:
Keywords:
Bladder cancer; Case report; Pregnancy; Radical cystectomy
Authors: Thomas W Flaig; Philippe E Spiess; Neeraj Agarwal; Rick Bangs; Stephen A Boorjian; Mark K Buyyounouski; Sam Chang; Tracy M Downs; Jason A Efstathiou; Terence Friedlander; Richard E Greenberg; Khurshid A Guru; Thomas Guzzo; Harry W Herr; Jean Hoffman-Censits; Christopher Hoimes; Brant A Inman; Masahito Jimbo; A Karim Kader; Subodh M Lele; Jeff Michalski; Jeffrey S Montgomery; Lakshminarayanan Nandagopal; Lance C Pagliaro; Sumanta K Pal; Anthony Patterson; Elizabeth R Plimack; Kamal S Pohar; Mark A Preston; Wade J Sexton; Arlene O Siefker-Radtke; Jonathan Tward; Jonathan L Wright; Lisa A Gurski; Alyse Johnson-Chilla Journal: J Natl Compr Canc Netw Date: 2020-03 Impact factor: 11.908