Literature DB >> 33407071

Identification of differentially expressed proteins and clinicopathological significance of HMGB2 in cervical cancer.

Xiao Han1,2, Siyi Zhong1,2, Pengnan Zhang2,3, Yanmei Liu1,2, Sangsang Shi1,2, Congquan Wu1,2, Shujun Gao4,5.   

Abstract

To investigate the complexity of proteomics in cervical cancer tissues, we used isobaric tags for relative and absolute quantitation (iTRAQ)-based mass spectrometry analysis on a panel of normal cervical tissues (N), high-grade squamous intraepithelial lesion tissues (HSIL) and cervical cancer tissues (CC). Total 72 differentially expressed proteins were identified both in CC vs N and CC vs HSIL. The expression of HMGB2 was markedly higher in CC than that in HSIL and N. High HMGB2 expression was significantly correlated with primary tumor size, invasion and tumor stage. The up-regulated HMGB2 was discovered to be associated with human cervical cancer. These findings suggest that HMGB2 may be a potentially prognostic biomarker and a target for the therapy of cervical cancer.

Entities:  

Keywords:  Cervical cancer; HMGB2; Proteomics; Tumor progression

Year:  2021        PMID： 33407071     DOI： 10.1186/s12014-020-09308-4

Source DB:  PubMed          Journal:  Clin Proteomics        ISSN： 1542-6416            Impact factor:   3.988


  36 in total

Review 1.  Antiangiogenics and immunotherapies in cervical cancer: an update and future's view.

Authors:  Daniela Luvero; Francesco Plotti; Salvatore Lopez; Giuseppe Scaletta; Stella Capriglione; Roberto Montera; Gianina Antonelli; Sara Ciuffreda; Raffaella Carassiti; Alice Oliveti; Roberto Angioli
Journal:  Med Oncol       Date:  2017-05-05       Impact factor: 3.064

Review 2.  Role of cytokines in genesis, progression and prognosis of cervical cancer.

Authors:  Prajakta Hemant Paradkar; Jayashree Vinay Joshi; Priyanka Nirmalsingh Mertia; Shubhada Vidyadhar Agashe; Rama Ashok Vaidya
Journal:  Asian Pac J Cancer Prev       Date:  2014

Review 3.  Clinical multi-omics strategies for the effective cancer management.

Authors:  Byong Chul Yoo; Kyung-Hee Kim; Sang Myung Woo; Jae Kyung Myung
Journal:  J Proteomics       Date:  2017-08-15       Impact factor: 4.044

4.  A panel of regulated proteins in serum from patients with cervical intraepithelial neoplasia and cervical cancer.

Authors:  Alexander P Boichenko; Natalia Govorukhina; Harry G Klip; A G J van der Zee; Coşkun Güzel; Theo M Luider; Rainer Bischoff
Journal:  J Proteome Res       Date:  2014-09-29       Impact factor: 4.466

5.  Identification of the C-Reactive Protein Interaction Network Using a Bioinformatics Approach Provides Insights into the Molecular Pathogenesis of Hepatocellular Carcinoma.

Authors:  Sha She; Lingyu Jiang; Zhenfang Zhang; Min Yang; Huaidong Hu; Peng Hu; Yong Liao; Yixuan Yang; Hong Ren
Journal:  Cell Physiol Biochem       Date:  2018-07-19

6.  Defining and measuring reproductive concerns of female cancer survivors.

Authors:  Lari Wenzel; Aysun Dogan-Ates; Rana Habbal; Ross Berkowitz; Donald P Goldstein; Marilyn Bernstein; Brenda Coffey Kluhsman; Kathryn Osann; Edward Newlands; Michael J Seckl; Barry Hancock; David Cella
Journal:  J Natl Cancer Inst Monogr       Date:  2005

7.  Silencing of high-mobility group box 2 (HMGB2) modulates cisplatin and 5-fluorouracil sensitivity in head and neck squamous cell carcinoma.

Authors:  Nazia Syed; Sandip Chavan; Nandini A Sahasrabuddhe; Santosh Renuse; Gajanan Sathe; Vishalakshi Nanjappa; Aneesha Radhakrishnan; Remya Raja; Sneha M Pinto; Anand Srinivasan; T S Keshava Prasad; Kotteazeth Srikumar; Harsha Gowda; Vani Santosh; David Sidransky; Joseph A Califano; Akhilesh Pandey; Aditi Chatterjee
Journal:  Proteomics       Date:  2015-01       Impact factor: 3.984

Review 8.  Update on novel therapeutic agents for cervical cancer.

Authors:  Josep Maria del Campo; Aleix Prat; Antonio Gil-Moreno; José Pérez; Marta Parera
Journal:  Gynecol Oncol       Date:  2008-06-09       Impact factor: 5.482

9.  i-Tracker: for quantitative proteomics using iTRAQ.

Authors:  Ian P Shadforth; Tom P J Dunkley; Kathryn S Lilley; Conrad Bessant
Journal:  BMC Genomics       Date:  2005-10-20       Impact factor: 3.969

10.  PANTHER version 11: expanded annotation data from Gene Ontology and Reactome pathways, and data analysis tool enhancements.

Authors:  Huaiyu Mi; Xiaosong Huang; Anushya Muruganujan; Haiming Tang; Caitlin Mills; Diane Kang; Paul D Thomas
Journal:  Nucleic Acids Res       Date:  2016-11-29       Impact factor: 16.971
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  1 in total

1.  Centromere protein U (CENPU) promotes gastric cancer cell proliferation and glycolysis by regulating high mobility group box 2 (HMGB2).

Authors:  Taozhi Deng; Xuemei Jiang; Zhoutao He; Manni Cai; Chaochao Chen; Zewen Xu
Journal:  Bioengineered       Date:  2021-12       Impact factor: 3.269
  1 in total

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