| Literature DB >> 33407005 |
Young-Il Kim1,2, Se-Mi Kim1,2, Su-Jin Park1,2,3, Eun-Ha Kim1,2, Kwang-Min Yu1,2, Jae-Hyung Chang1, Eun Ji Kim1, Mark Anthony B Casel1,2, Rare Rollon1, Seung-Gyu Jang1, Jihye Um4, Min-Suk Song1,2, Hye Won Jeong1, Eung-Gook Kim1, Yeonjae Kim4, So Yeon Kim4, Jun-Sun Park4, Mi Sun Park5, Geun-Yong Kwon6, Sang Gu Yeo5, Shin-Ae Lee7, Youn Jung Choi7, Jae U Jung7, Young Ki Choi1,2.
Abstract
Cases of laboratory-confirmed SARS-CoV-2 reinfection have been reported in a number of countries. Further, the level of natural immunity induced by SARS-CoV-2 infection is not fully clear, nor is it clear if a primary infection is protective against reinfection. To investigate the potential association between serum antibody titres and reinfection of SARS-CoV-2, ferrets with different levels of NAb titres after primary SARS-CoV-2 infection were subjected to reinfection with a heterologous SARS-CoV-2 strain. All heterologous SARS-CoV-2 reinfected ferrets showed active virus replication in the upper respiratory and gastro-intestinal tracts. However, the high NAb titre group showed attenuated viral replication and rapid viral clearance. In addition, direct-contact transmission was observed only from reinfected ferrets with low NAb titres (<20), and not from other groups. Further, lung histopathology demonstrated the presence of limited inflammatory regions in the high NAb titre groups compared with control and low NAb groups. This study demonstrates a close correlation between a low NAb titre and SARS-CoV-2 reinfection in a recovered ferret reinfection model.Entities:
Keywords: COVID-19; SARS-CoV-2; ferret model; neutralizing antibody; reinfection
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Year: 2021 PMID： 33407005 PMCID： PMC7832474 DOI： 10.1080/22221751.2021.1872352
Source DB: PubMed Journal: Emerg Microbes Infect ISSN： 2222-1751 Impact factor: 7.163