| Literature DB >> 33406768 |
Lin Peng1, Huixia Yang1, Yao Ye2, Zhi Ma1, Christina Kuhn3, Martina Rahmeh1, Sven Mahner1, Antonis Makrigiannakis4, Udo Jeschke1,5, Viktoria von Schönfeldt3.
Abstract
Peroxisome proliferator-activated receptors (PPARα, PPARβ/δ, and PPARγ) belong to the transcription factor family, and they are highly expressed in all types of trophoblast during pregnancy. The present review discusses currently published papers that are related to the regulation of PPARs via lipid metabolism, glucose metabolism, and amino acid metabolism to affect trophoblast physiological conditions, including differentiation, maturation, secretion, fusion, proliferation, migration, and invasion. Recent pieces of evidence have proven that the dysfunctions of PPARs in trophoblast lead to several related pregnancy diseases such as recurrent miscarriage, preeclampsia, intrauterine growth restriction, and gestational diabetes mellitus. Moreover, the underlying mechanisms of PPARs in the control of these processes have been discussed as well. Finally, this review's purposes are to provide more knowledge about the role of PPARs in normal and disturbed pregnancy with trophoblast, so as to find PPAR ligands as a potential therapeutic target in the treatment and prevention of adverse pregnancy outcomes.Entities:
Keywords: cytotrophoblast; extravillous trophoblast; functions; peroxisome proliferator-activated receptors (PPARs)
Year: 2021 PMID： 33406768 DOI： 10.3390/ijms22010433
Source DB: PubMed Journal: Int J Mol Sci ISSN： 1422-0067 Impact factor: 5.923