| Literature DB >> 33406329 |
Ayumu Arakawa1, Hitoshi Ichikawa1, Takashi Kubo1, Noriko Motoi1, Tadashi Kumamoto1, Miho Nakajima1, Kan Yonemori1, Emi Noguchi1, Kuniko Sunami1, Kouya Shiraishi1, Hiroki Kakishima1, Hiroshi Yoshida1, Tomoro Hishiki1, Naonori Kawakubo1, Takafumi Kuroda1, Takako Kiyokawa1, Kyosuke Yamada1, Nozomu Yanaihara1, Kazuaki Takahashi1, Aikou Okamoto1, Shinsuke Hirabayashi1, Daisuke Hasegawa1, Atsushi Manabe1, Kentaro Ono1, Masaki Matsuoka1, Yasuhito Arai1, Yosuke Togashi1, Tatsuhiro Shibata1, Hiroyoshi Nishikawa1, Kazunori Aoki1, Noboru Yamamoto1, Takashi Kohno1, Chitose Ogawa1.
Abstract
Two cases of pediatric lung cancer (in 23-month-old and 6-year-old boys) resulting from mother-to-infant transmission of uterine cervical tumors were incidentally detected during routine next-generation sequencing of paired samples of tumor and normal tissue. Spontaneous regression of some lesions in the first child and slow growth of the tumor mass in the second child suggested the existence of alloimmune responses against the transmitted tumors. Immune checkpoint inhibitor therapy with nivolumab led to a strong regression of all remaining tumors in the first child. (Funded by the Japan Agency for Medical Research and Development and others; TOP-GEAR UMIN Clinical Trials Registry number, UMIN000011141.).Entities:
Mesh：
Year: 2021 PMID： 33406329 DOI： 10.1056/NEJMoa2030391
Source DB: PubMed Journal: N Engl J Med ISSN： 0028-4793 Impact factor: 91.245