| Literature DB >> 33405198 |
Rowan Saloner1,2, Emily W Paolillo1,2, Robert K Heaton2, David J Grelotti2, Murray B Stein2, Andrew H Miller3, J Hampton Atkinson2, Scott L Letendre2,4, Ronald J Ellis2,5, Igor Grant2, Jennifer E Iudicello2, David J Moore6.
Abstract
We examined the joint effects of depressive symptoms (Beck Depression Inventory-II (BDI-II)) and systemic inflammation (plasma C-reactive protein (CRP)) on longitudinal profiles of neurocognition in a cohort of 143 people with HIV (PWH) on antiretroviral therapy. Global neurocognition, processing speed, motor skills, and attention/working memory all worsened as CRP increased but only among PWH who, on average, exhibited moderate to severe depressive symptoms (BDI-II > 22). Findings suggest that some PWH with chronically elevated depressive symptoms may have an inflammatory subtype of depression and a particular vulnerability to neurocognitive changes that may respond to drugs targeting inflammation or its neural sequelae.Entities:
Keywords: C-reactive protein; Cognition; Depression; HIV-associated neurocognitive disorder; Inflammation; Processing speed
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Year: 2021 PMID： 33405198 PMCID： PMC8284079 DOI： 10.1007/s13365-020-00925-1
Source DB: PubMed Journal: J Neurovirol ISSN： 1355-0284 Impact factor: 3.739