| Literature DB >> 33404925 |
Xiang Peng1,2, Yani Wang1,2, Xiangwen Xi1,2, Ying Jia1,2, Jiangtian Tian1,2, Bo Yu1,2, Jinwei Tian3,4,5.
Abstract
The coronavirus disease 19 (COVID-19) pandemic poses a serious global threat to human health and the economy. Based on accumulating evidence, its continuous progression involves not only pulmonary injury but also damage to the cardiovascular system due to intertwined pathophysiological risks. As a point of convergence in the pathophysiologic process between COVID-19 and heart failure (HF), cytokine storm induces the progression of COVID-19 in patients presenting pre-existing or new onset myocardial damage and even HF. Cytokine storm, as a trigger of the progression of HF in patients with COVID-19, has become a novel focus to explore therapies for target populations. In this review, we briefly introduce the basis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and illuminate the mechanism and links among COVID-19, cytokine storm, and HF. Furthermore, we discuss drugs and therapeutic targets for patients with COVID-19 and HF.Entities:
Keywords: COVID-19; Cytokine storm; Heart failure; Treatment
Mesh：
Substances：
Year: 2021 PMID： 33404925 PMCID： PMC7786163 DOI： 10.1007/s10557-020-07120-8
Source DB: PubMed Journal: Cardiovasc Drugs Ther ISSN： 0920-3206 Impact factor: 3.727