Literature DB >> 33404855

Gastric-type cervical adenocarcinoma with squamous differentiation: buried in adenosquamous carcinomas?

Hiroshi Yoshida1, Tomoaki Naka2, Mayumi Kobayashi-Kato3, Nao Kikkawa4, Yasuhito Tanase3, Masaya Uno3, Mitsuya Ishikawa3, Tomoyasu Kato3.   

Abstract

Gastric-type adenocarcinoma (GAS) of the cervix is a human papilloma virus (HPV)-independent, aggressive, and chemo-resistant adenocarcinoma. However, although the histopathological features of GAS have been extensively investigated, squamous differentiation has not been mentioned. This study aimed to elucidate the frequency of GAS with squamous differentiation and describe their clinicopathological characteristics. We retrospectively evaluated 78 patients with GAS (n = 13) and adenosquamous carcinoma (n = 65) diagnosed between 2000 and 2020. Two patients with GAS with squamous differentiation were identified. Both tumors showed advanced stage (pT2bN1) and had predominant GAS and merged squamous cell carcinoma components without p16-block positivity and HPV DNA. Gastric-type adenocarcinoma in situ was confirmed in both cases. Some cases of GAS could show squamous differentiation mimicking the usual, HPV-associated, adenosquamous carcinoma. GAS with squamous differentiation is recognized as an HPV-independent cancer.

Entities:  

Keywords:  Adenosquamous carcinoma; Cervical cancer; Gastric-type adenocarcinoma; HPV-independent cancer; Squamous differentiation

Year:  2021        PMID： 33404855     DOI： 10.1007/s00428-020-02997-0

Source DB:  PubMed          Journal:  Virchows Arch        ISSN： 0945-6317            Impact factor:   4.064


  13 in total

1.  HPV prevalence and genotypes in different histological subtypes of cervical adenocarcinoma, a worldwide analysis of 760 cases.

Authors:  Edyta C Pirog; Belen Lloveras; Anco Molijn; Sara Tous; Núria Guimerà; Maria Alejo; Omar Clavero; Joellen Klaustermeier; David Jenkins; Wim Gv Quint; Francesc Xavier Bosch; Laia Alemany; Silvia de Sanjosé
Journal:  Mod Pathol       Date:  2014-04-25       Impact factor: 7.842

2.  Diagnostic Algorithmic Proposal Based on Comprehensive Immunohistochemical Evaluation of 297 Invasive Endocervical Adenocarcinomas.

Authors:  Simona Stolnicu; Iulia Barsan; Lien Hoang; Prusha Patel; Luis Chiriboga; Cristina Terinte; Anna Pesci; Sarit Aviel-Ronen; Takako Kiyokawa; Isabel Alvarado-Cabrero; Malcolm C Pike; Esther Oliva; Kay J Park; Robert A Soslow
Journal:  Am J Surg Pathol       Date:  2018-08       Impact factor: 6.394

Review 3.  Gastric-type Adenocarcinoma of the Cervix: Tumor With Wide Range of Histologic Appearances.

Authors:  Edyta C Pirog; Kay J Park; Takako Kiyokawa; Xun Zhang; Wen Chen; David Jenkins; Wim Quint
Journal:  Adv Anat Pathol       Date:  2019-01       Impact factor: 3.875

4.  Chemoresistance of Gastric-Type Mucinous Carcinoma of the Uterine Cervix: A Study of the Sankai Gynecology Study Group.

Authors:  Atsumi Kojima; Muneaki Shimada; Yoshiki Mikami; Shoji Nagao; Nobuhiro Takeshima; Toru Sugiyama; Norihiro Teramoto; Takako Kiyokawa; Junzo Kigawa; Ryuichiro Nishimura
Journal:  Int J Gynecol Cancer       Date:  2018-01       Impact factor: 3.437

5.  International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.

Authors:  Simona Stolnicu; Iulia Barsan; Lien Hoang; Prusha Patel; Cristina Terinte; Anna Pesci; Sarit Aviel-Ronen; Takako Kiyokawa; Isabel Alvarado-Cabrero; Malcolm C Pike; Esther Oliva; Kay J Park; Robert A Soslow
Journal:  Am J Surg Pathol       Date:  2018-02       Impact factor: 6.394

6.  Absence of high-risk human papillomavirus (HPV) detection in endocervical adenocarcinoma with gastric morphology and phenotype.

Authors:  Yasuki Kusanagi; Atsumi Kojima; Yoshiki Mikami; Takako Kiyokawa; Tamotsu Sudo; Satoshi Yamaguchi; Ryuichiro Nishimura
Journal:  Am J Pathol       Date:  2010-09-09       Impact factor: 4.307

7.  HPV-negative Gastric Type Adenocarcinoma In Situ of the Cervix: A Spectrum of Rare Lesions Exhibiting Gastric and Intestinal Differentiation.

Authors:  Karen L Talia; Colin J R Stewart; Brooke E Howitt; Marisa R Nucci; W Glenn McCluggage
Journal:  Am J Surg Pathol       Date:  2017-08       Impact factor: 6.394

8.  Analysis of gastric-type mucinous carcinoma of the uterine cervix - An aggressive tumor with a poor prognosis: A multi-institutional study.

Authors:  Shin Nishio; Yoshiki Mikami; Hideki Tokunaga; Nobuo Yaegashi; Toyomi Satoh; Motoaki Saito; Aikou Okamoto; Takahiro Kasamatsu; Tsutomu Miyamoto; Tanri Shiozawa; Yumiko Yoshioka; Masaki Mandai; Atsumi Kojima; Kazuhiro Takehara; Eisuke Kaneki; Hiroaki Kobayashi; Tsunehisa Kaku; Kimio Ushijima; Toshiharu Kamura
Journal:  Gynecol Oncol       Date:  2019-01-29       Impact factor: 5.482

9.  Gastric morphology and immunophenotype predict poor outcome in mucinous adenocarcinoma of the uterine cervix.

Authors:  Atsumi Kojima; Yoshiki Mikami; Tamotsu Sudo; Satoshi Yamaguchi; Yasuki Kusanagi; Masaharu Ito; Ryuichiro Nishimura
Journal:  Am J Surg Pathol       Date:  2007-05       Impact factor: 6.394

10.  Cervical adenosquamous carcinoma: detailed analysis of morphology, immunohistochemical profile, and clinical outcomes in 59 cases.

Authors:  Simona Stolnicu; Lien Hoang; Orsolya Hanko-Bauer; Iulia Barsan; Cristina Terinte; Anna Pesci; Sarit Aviel-Ronen; Takako Kiyokawa; Isabel Alvarado-Cabrero; Esther Oliva; Kay J Park; Robert A Soslow
Journal:  Mod Pathol       Date:  2018-09-26       Impact factor: 7.842
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  1 in total

Review 1.  Molecular Pathology of Human Papilloma Virus-Negative Cervical Cancers.

Authors:  Hiroshi Yoshida; Kouya Shiraishi; Tomoyasu Kato
Journal:  Cancers (Basel)       Date:  2021-12-17       Impact factor: 6.639
  1 in total

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