Literature DB >> 33404291

Did evolution choose Atg11 as the scaffolding platform beyond selective autophagy?

Yuxiang J Huang1,2, Daniel J Klionsky1,2.   

Abstract

It has been well established that Atg11 plays a critical role in selective macroautophagy/autophagy, but not in nonselective autophagy in the budding yeast Saccharomyces cerevisiae. However, its mammalian ortholog RB1CC1/FIP200 is indispensable for both types of autophagy, and the molecular mechanism behind its function is a mystery. Recently, Pan et al. showed that in the fission yeast Schizosaccharomyces pombe, Atg11 could also promote nonselective autophagy via activation of Atg1 kinase. These results prompt an interesting idea that Atg11 might have gained an additional ability to mediate nonselective autophagy through evolution.

Entities:  

Keywords:  Lysosome; macroautophagy; stress; vacuole; yeast

Mesh:

Substances:

Year:  2021        PMID: 33404291      PMCID: PMC8078765          DOI: 10.1080/15548627.2021.1872176

Source DB:  PubMed          Journal:  Autophagy        ISSN: 1554-8627            Impact factor:   16.016


  5 in total

Review 1.  Mechanistic Insights into the Role of Atg11 in Selective Autophagy.

Authors:  Katarzyna Zientara-Rytter; Suresh Subramani
Journal:  J Mol Biol       Date:  2019-06-22       Impact factor: 5.469

2.  Hierarchy of Atg proteins in pre-autophagosomal structure organization.

Authors:  Kuninori Suzuki; Yuka Kubota; Takayuki Sekito; Yoshinori Ohsumi
Journal:  Genes Cells       Date:  2007-02       Impact factor: 1.891

3.  Conserved and unique features of the fission yeast core Atg1 complex.

Authors:  Tamiza Nanji; Xu Liu; Leon H Chew; Franco K Li; Maitree Biswas; Zhong-Qiu Yu; Shan Lu; Meng-Qiu Dong; Li-Lin Du; Daniel J Klionsky; Calvin K Yip
Journal:  Autophagy       Date:  2017-11-23       Impact factor: 16.016

4.  Cvt9/Gsa9 functions in sequestering selective cytosolic cargo destined for the vacuole.

Authors:  J Kim; Y Kamada; P E Stromhaug; J Guan; A Hefner-Gravink; M Baba; S V Scott; Y Ohsumi; W A Dunn; D J Klionsky
Journal:  J Cell Biol       Date:  2001-04-16       Impact factor: 10.539

5.  Atg1 kinase in fission yeast is activated by Atg11-mediated dimerization and cis-autophosphorylation.

Authors:  Zhao-Qian Pan; Guang-Can Shao; Xiao-Man Liu; Quan Chen; Meng-Qiu Dong; Li-Lin Du
Journal:  Elife       Date:  2020-09-10       Impact factor: 8.140

  5 in total

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