Literature DB >> 33403031

The oncogenic role of protein kinase D3 in cancer.

Yan Liu1,2, Hang Song3, Yehui Zhou4, Xinxing Ma4, Jing Xu3, Zhenghong Yu5, Liming Chen2.   

Abstract

Protein kinase D3 (PRKD3), a serine/threonine kinase, belongs to protein kinase D family, which contains three members: PRKD1, PRKD2, and PRKD3. PRKD3 is activated by many stimuli including phorbol esters, and G-protein-coupled receptor agonists. PRKD3 promotes cancer cell proliferation, growth, migration, and invasion in various tumor types including colorectal, gastric, hepatic, prostate, and breast cancer. Accumulating data supports that PRKD3 is a promising therapeutic target for treatment of cancer. This review discusses the functions and mechanisms of PRKD3 in promoting tumorigenesis and tumor progression of various tumor types as well as the latest developments of small-molecule inhibitors selection for PRKD/PRKD3. © The author(s).

Entities:  

Keywords:  Cancer progression; Protein kinase D3

Year:  2021        PMID： 33403031      PMCID： PMC7778554          DOI： 10.7150/jca.50899

Source DB:  PubMed          Journal:  J Cancer        ISSN： 1837-9664            Impact factor:   4.207


  60 in total

1.  Snail-activated long non-coding RNA PCA3 up-regulates PRKD3 expression by miR-1261 sponging, thereby promotes invasion and migration of prostate cancer cells.

Authors:  Jin-Hua He; Bao-Xia Li; Ze-Ping Han; Mao-Xian Zou; Li Wang; Yu-Bing Lv; Jia-Bin Zhou; Ming-Rong Cao; Yu-Guang Li; Jing-Zhi Zhang
Journal:  Tumour Biol       Date:  2016-10-14

2.  Protein kinase D potentiates DNA synthesis and cell proliferation induced by bombesin, vasopressin, or phorbol esters in Swiss 3T3 cells.

Authors:  E Zhukova; J Sinnett-Smith; E Rozengurt
Journal:  J Biol Chem       Date:  2001-08-20       Impact factor: 5.157

3.  PKD2 mediates multi-drug resistance in breast cancer cells through modulation of P-glycoprotein expression.

Authors:  Jiao Chen; Libing Lu; Yun Feng; Hui Wang; Lila Dai; Yan Li; Ping Zhang
Journal:  Cancer Lett       Date:  2010-10-12       Impact factor: 8.679

Review 4.  PKD at the crossroads of DAG and PKC signaling.

Authors:  Qiming J Wang
Journal:  Trends Pharmacol Sci       Date:  2006-05-06       Impact factor: 14.819

5.  3,5-diarylazoles as novel and selective inhibitors of protein kinase D.

Authors:  Gabriel G Gamber; Erik Meredith; Qingming Zhu; Wanlin Yan; Chang Rao; Michael Capparelli; Robin Burgis; Istvan Enyedy; Ji-Hu Zhang; Nicolas Soldermann; Kimberley Beattie; Olga Rozhitskaya; Keith A Koch; Nikos Pagratis; Vinayak Hosagrahara; Richard B Vega; Timothy A McKinsey; Lauren Monovich
Journal:  Bioorg Med Chem Lett       Date:  2011-01-11       Impact factor: 2.823

6.  Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells.

Authors:  Ian M Evans; Azadeh Bagherzadeh; Mark Charles; Tony Raynham; Chris Ireson; Alexandra Boakes; Lloyd Kelland; Ian C Zachary
Journal:  Biochem J       Date:  2010-08-01       Impact factor: 3.857

7.  Protein kinases D2 and D3 are novel growth regulators in HCC1806 triple-negative breast cancer cells.

Authors:  Qin Hao; Raymond McKenzie; Huachen Gan; Hua Tang
Journal:  Anticancer Res       Date:  2013-02       Impact factor: 2.480

8.  Protein kinase D regulates basolateral membrane protein exit from trans-Golgi network.

Authors:  Charles Yeaman; M Inmaculada Ayala; Jessica R Wright; Frederic Bard; Carine Bossard; Agnes Ang; Yusuke Maeda; Thomas Seufferlein; Ira Mellman; W James Nelson; Vivek Malhotra
Journal:  Nat Cell Biol       Date:  2004-01-25       Impact factor: 28.824

9.  Design, Synthesis, and Biological Evaluation of PKD Inhibitors.

Authors:  Kara M George; Marie-Céline Frantz; Karla Bravo-Altamirano; Courtney R Lavalle; Manuj Tandon; Stephanie Leimgruber; Elizabeth R Sharlow; John S Lazo; Q Jane Wang; Peter Wipf
Journal:  Pharmaceutics       Date:  2011       Impact factor: 6.321

10.  Pharmacologic reversion of epigenetic silencing of the PRKD1 promoter blocks breast tumor cell invasion and metastasis.

Authors:  Sahra Borges; Heike Döppler; Edith A Perez; Cathy A Andorfer; Zhifu Sun; Panos Z Anastasiadis; E Thompson; Xochiquetzal J Geiger; Peter Storz
Journal:  Breast Cancer Res       Date:  2013-08-23       Impact factor: 6.466
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  3 in total

1.  Proteomic and Phosphoproteomic Profiling Reveals the Oncogenic Role of Protein Kinase D Family Kinases in Cholangiocarcinoma.

Authors:  Yun Lu; Xiangyu Li; Kai Zhao; Yuanxin Shi; Zhengdong Deng; Wei Yao; Jianming Wang
Journal:  Cells       Date:  2022-09-30       Impact factor: 7.666

2.  Identification of Key Circulating Exosomal microRNAs in Gastric Cancer.

Authors:  Xiaoqing Qian; Feng Xie; Huabing Wei; Daxiang Cui
Journal:  Front Oncol       Date:  2021-07-16       Impact factor: 6.244

Review 3.  Small-Molecule Inhibitor Targeting Protein Kinase D: A Potential Therapeutic Strategy.

Authors:  Die Lv; Hongli Chen; Yun Feng; Bomiao Cui; Yingzhu Kang; Ping Zhang; Min Luo; Jiao Chen
Journal:  Front Oncol       Date:  2021-06-24       Impact factor: 6.244
  3 in total

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