CASE DESCRIPTION: 37-year-old female with PCR-RT swab for COVID-19 positive, with neurological manifestation as a result of internal carotid artery occlusion. CLINICAL FINDINGS: Nasal congestion and sneezing of 5 days duration; pulsatile headache in the left hemicranium 3 days prior to admission, with intensity 6/10 according to the visual analogue scale, accompanied by phosphenes, photophobia and diplopia; with subsequent developing right hemiparesis over a 26-hour period. TREATMENT AND RESULT: She was given medical management with oral antiplatelet agents and anticoagulants (subcutaneous and oral) during his hospitalization, it was not possible to perform thrombolysis and thrombectomy due to the high risk of complications. He was discharged at 14 days, without functional limitation, symmetrical strength in upper and lower limbs, bilateral visual acuity 20/20, denying headache. CLINICAL RELEVANCE: The case presented here describes a pattern in how data supporting an association between COVID-19 and stroke in young populations with or without typical vascular risk factors, sometimes with only mild respiratory symptoms, is increasing. Prospective studies are required to further evaluate this association, as well as anticoagulation studies to prevent these potentially life-threatening events.
CASE DESCRIPTION: 37-year-old female with PCR-RT swab for COVID-19 positive, with neurological manifestation as a result of internal carotid artery occlusion. CLINICAL FINDINGS: Nasal congestion and sneezing of 5 days duration; pulsatile headache in the left hemicranium 3 days prior to admission, with intensity 6/10 according to the visual analogue scale, accompanied by phosphenes, photophobia and diplopia; with subsequent developing right hemiparesis over a 26-hour period. TREATMENT AND RESULT: She was given medical management with oral antiplatelet agents and anticoagulants (subcutaneous and oral) during his hospitalization, it was not possible to perform thrombolysis and thrombectomy due to the high risk of complications. He was discharged at 14 days, without functional limitation, symmetrical strength in upper and lower limbs, bilateral visual acuity 20/20, denying headache. CLINICAL RELEVANCE: The case presented here describes a pattern in how data supporting an association between COVID-19 and stroke in young populations with or without typical vascular risk factors, sometimes with only mild respiratory symptoms, is increasing. Prospective studies are required to further evaluate this association, as well as anticoagulation studies to prevent these potentially life-threatening events.
Authors: Miguel Jiménez-Alcázar; Chandini Rangaswamy; Rachita Panda; Josephine Bitterling; Yashin J Simsek; Andy T Long; Rostyslav Bilyy; Veit Krenn; Christoph Renné; Thomas Renné; Stefan Kluge; Ulf Panzer; Ryushin Mizuta; Hans Georg Mannherz; Daisuke Kitamura; Martin Herrmann; Markus Napirei; Tobias A Fuchs Journal: Science Date: 2017-12-01 Impact factor: 47.728
Authors: Moritz Leppkes; Christian Maueröder; Sebastian Hirth; Stefanie Nowecki; Claudia Günther; Ulrike Billmeier; Susanne Paulus; Mona Biermann; Luis E Munoz; Markus Hoffmann; Dane Wildner; Andrew L Croxford; Ari Waisman; Kerri Mowen; Dieter E Jenne; Veit Krenn; Julia Mayerle; Markus M Lerch; Georg Schett; Stefan Wirtz; Markus F Neurath; Martin Herrmann; Christoph Becker Journal: Nat Commun Date: 2016-03-11 Impact factor: 14.919
Authors: Shadi Yaghi; Koto Ishida; Jose Torres; Brian Mac Grory; Eytan Raz; Kelley Humbert; Nils Henninger; Tushar Trivedi; Kaitlyn Lillemoe; Shazia Alam; Matthew Sanger; Sun Kim; Erica Scher; Seena Dehkharghani; Michael Wachs; Omar Tanweer; Frank Volpicelli; Brian Bosworth; Aaron Lord; Jennifer Frontera Journal: Stroke Date: 2020-05-20 Impact factor: 7.914
Authors: Jose M Adrover; Alejandra Aroca-Crevillén; Georgiana Crainiciuc; Fernando Ostos; Yeny Rojas-Vega; Andrea Rubio-Ponce; Catia Cilloniz; Elena Bonzón-Kulichenko; Enrique Calvo; Daniel Rico; María A Moro; Christian Weber; Ignacio Lizasoaín; Antoni Torres; Jesús Ruiz-Cabello; Jesús Vázquez; Andrés Hidalgo Journal: Nat Immunol Date: 2020-01-13 Impact factor: 25.606