KristÝna ProchÁzkovÁ1, KristÝna PivovarČÍkovÁ2, Milena RouŠarovÁ3, Josef VodiČka1, Petr HoŠek4, Inka TŘeŠkovÁ5, OndŘej Hes2, Radek KuČera6, OndŘej TopolČan5, Vladislav TŘeŠka1. 1. Department of Surgery, Faculty of Medicine in Pilsen, Charles University and University Hospital, Pilsen, Czech Republic. 2. Department of Pathology, Faculty of Medicine in Pilsen, Charles University and University Hospital, Pilsen, Czech Republic. 3. Czech National Oncological Register, Pilsen, Czech Republic. 4. Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic. 5. Department of Plastic Surgery, Faculty of Medicine in Pilsen, Charles University and University Hospital, Pilsen, Czech Republic. 6. Department of Immunochemistry Diagnostics Faculty of Medicine in Pilsen, Charles University and University Hospital, Pilsen, Czech Republic kucerar@fnplzen.cz.
Abstract
BACKGROUND/AIM: The aim of this study was to determine the importance of surgical treatment, utility of hormone receptor status and selected biomarkers in the prognosis of patients with liver metastases from breast cancer (BCLM). PATIENTS AND METHODS: Thirty female underwent surgery for BCLM between 1/2000 and 1/2019. RESULTS: The type of surgery (resection/radiofrequency ablation) had no impact on overall survival (OS) - (p=0.894). Having more than one BCLM (p=0.003), expression of human epidermal receptor 2 in metastases (p=0.034), as well as an elevated presurgical level of carbohydrate antigen 19-9 (p=0.017) and postsurgical thymidine kinase (p=0.034) were negative prognostics factor for recurrence-free survival. The factors affecting OS included the number of liver procedures (p=0.021), the degree of proliferative activity (p=0.008) and elevated postsurgical carcinoembryonic antigen level (p=0.038). CONCLUSION: The type of surgery had no impact on OS. Markers and hormonal status of liver metastases are important factors affecting prognosis. Copyright
BACKGROUND/AIM: The aim of this study was to determine the importance of surgical treatment, utility of hormone receptor status and selected biomarkers in the prognosis of patients with liver metastases from breast cancer (BCLM). PATIENTS AND METHODS: Thirty female underwent surgery for BCLM between 1/2000 and 1/2019. RESULTS: The type of surgery (resection/radiofrequency ablation) had no impact on overall survival (OS) - (p=0.894). Having more than one BCLM (p=0.003), expression of human epidermal receptor 2 in metastases (p=0.034), as well as an elevated presurgical level of carbohydrate antigen 19-9 (p=0.017) and postsurgical thymidine kinase (p=0.034) were negative prognostics factor for recurrence-free survival. The factors affecting OS included the number of liver procedures (p=0.021), the degree of proliferative activity (p=0.008) and elevated postsurgical carcinoembryonic antigen level (p=0.038). CONCLUSION: The type of surgery had no impact on OS. Markers and hormonal status of liver metastases are important factors affecting prognosis. Copyright
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