Literature DB >> 33402118

Role of long non-coding RNA H19 in therapy resistance of digestive system cancers.

Jingting Wang1, Xiao Ma1, Hai Si1, Zhongjun Ma1, Yan Ma2, Jing Wang3,4, Bangwei Cao1.   

Abstract

Digestive system cancers are associated with high morbidity and mortality. Chemotherapy and radiotherapy are the main treatment modalities for these cancers. However, the development of therapy resistance leads to high rates of tumor recurrence and metastasis, resulting in dismal prognosis. Long non-coding RNA (LncRNA) H19, one of the most intriguing non-coding RNAs, has been shown to play a key role in the development and therapy resistance of various digestive system cancers (including hepatocellular carcinoma, colorectal cancer, pancreatic ductal adenocarcinoma, esophageal carcinoma, gastric cancer, and biliary system cancer) by regulating the abnormal expression of genes. In this review, we discuss the potential mechanisms of LncRNA H19 related therapy resistance in the context of digestive system cancers. LncRNA H19 is a potential novel therapeutic target for amelioration of cancer therapy resistance.

Entities:  

Keywords:  Chemoresistant; Digestive system cancer; LncRNA-H19; Radioresistant

Year:  2021        PMID： 33402118      PMCID： PMC7786989          DOI： 10.1186/s10020-020-00255-2

Source DB:  PubMed          Journal:  Mol Med        ISSN： 1076-1551            Impact factor:   6.354


  52 in total

1.  Non-coding transcripts in the H19 imprinting control region mediate gene silencing in transgenic Drosophila.

Authors:  Stefan Schoenfelder; Guillaume Smits; Peter Fraser; Wolf Reik; Renato Paro
Journal:  EMBO Rep       Date:  2007-10-19       Impact factor: 8.807

2.  Cancer statistics, 2019.

Authors:  Rebecca L Siegel; Kimberly D Miller; Ahmedin Jemal
Journal:  CA Cancer J Clin       Date:  2019-01-08       Impact factor: 508.702

3.  High level of lncRNA H19 expression is associated with shorter survival in esophageal squamous cell cancer patients.

Authors:  Xiangyu Li; Haijun Yang; Jianbo Wang; Xiufang Li; Zhirui Fan; Jing Zhao; Lan Liu; Mingzhi Zhang; Mariusz Adam Goscinski; Junsheng Wang; Ruiping Xu; Huijie Fan; Huixiang Li; Zhenhe Suo
Journal:  Pathol Res Pract       Date:  2019-09-16       Impact factor: 3.250

4.  The Effect of LncRNA H19/miR-194-5p Axis on the Epithelial-Mesenchymal Transition of Colorectal Adenocarcinoma.

Authors:  Chang-Feng Li; Yong-Chao Li; Yun Wang; Li-Bo Sun
Journal:  Cell Physiol Biochem       Date:  2018-10-02

5.  Long non-coding RNA H19 regulates glioma angiogenesis and the biological behavior of glioma-associated endothelial cells by inhibiting microRNA-29a.

Authors:  Peng Jia; Heng Cai; Xiaobai Liu; Jiajia Chen; Jun Ma; Ping Wang; Yunhui Liu; Jian Zheng; Yixue Xue
Journal:  Cancer Lett       Date:  2016-08-16       Impact factor: 8.679

6.  Long non-coding RNAs as a determinant of cancer drug resistance: Towards the overcoming of chemoresistance via modulation of lncRNAs.

Authors:  Wenxiao Jiang; Jun Xia; Shangdan Xie; Ruanmin Zou; Shuya Pan; Zhi-Wei Wang; Yehuda G Assaraf; Xueqiong Zhu
Journal:  Drug Resist Updat       Date:  2020-02-25       Impact factor: 18.500

7.  Reverse resistance to radiation in KYSE-150R esophageal carcinoma cell after epidermal growth factor receptor signal pathway inhibition by cetuximab.

Authors:  Zhao Jing; Ling Gong; Cong-Ying Xie; Li Zhang; Hua-Fang Su; Xia Deng; Shi-Xiu Wu
Journal:  Radiother Oncol       Date:  2009-09-08       Impact factor: 6.280

8.  Long noncoding RNA H19 indicates a poor prognosis of colorectal cancer and promotes tumor growth by recruiting and binding to eIF4A3.

Authors:  Dong Han; Xu Gao; Meng Wang; Yu Qiao; Ya Xu; Jing Yang; Nazhen Dong; Jun He; Qian Sun; Guixiang Lv; Changqing Xu; Ji Tao; Ning Ma
Journal:  Oncotarget       Date:  2016-04-19

Review 9.  Targeting Epithelial-Mesenchymal Transition (EMT) to Overcome Drug Resistance in Cancer.

Authors:  Bowen Du; Joong Sup Shim
Journal:  Molecules       Date:  2016-07-22       Impact factor: 4.411

10.  Carcinoma-associated fibroblasts promote the stemness and chemoresistance of colorectal cancer by transferring exosomal lncRNA H19.

Authors:  Jing Ren; Liang Ding; Dongya Zhang; Guoping Shi; Qianyun Xu; Sunan Shen; Yaping Wang; Tingting Wang; Yayi Hou
Journal:  Theranostics       Date:  2018-06-24       Impact factor: 11.556
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  4 in total

1.  A novel long noncoding RNA SP100-AS1 induces radioresistance of colorectal cancer via sponging miR-622 and stabilizing ATG3.

Authors:  You Zhou; Yingjie Shao; Wenwei Hu; Jinping Zhang; Yufang Shi; Xiangyin Kong; Jingting Jiang
Journal:  Cell Death Differ       Date:  2022-08-17       Impact factor: 12.067

2.  LncRNA H19 modulated by miR-146b-3p/miR-1539-mediated allelic regulation in transarterial chemoembolization of hepatocellular carcinoma.

Authors:  Yemei Song; Huaixin Xing; Liqing Zhou; Nasha Zhang; Ming Yang
Journal:  Arch Toxicol       Date:  2021-07-12       Impact factor: 5.153

3.  Long non-coding RNA SLC25A25-AS1 exhibits oncogenic roles in non-small cell lung cancer by regulating the microRNA-195-5p/ITGA2 axis.

Authors:  Jinqin Chen; Chengpeng Gao; Wei Zhu
Journal:  Oncol Lett       Date:  2021-05-16       Impact factor: 2.967

Review 4.  Mechanism underlying circRNA dysregulation in the TME of digestive system cancer.

Authors:  Zeyu Wu; Xiao Yu; Shuijun Zhang; Yuting He; Wenzhi Guo
Journal:  Front Immunol       Date:  2022-09-27       Impact factor: 8.786
  4 in total

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