Bayaki Saka1, Sefako Abla Akakpo2, Julienne Noude Teclessou3, Piham Gnossike4, Saliou Adam5, Garba Mahamadou2, Panawé Kassang2, Yvette Elegbede6, Abas Mouhari-Toure7, Tchin Darre8, Koussake Kombate3, Palokinam Pitché2. 1. Dermatology and STIs Department, Service de dermatolgie et IST, CHU Sylvanus Olympio, Université de Lomé, BP. 30785, Lomé, Togo. barthelemysaka@yahoo.fr. 2. Dermatology and STIs Department, Service de dermatolgie et IST, CHU Sylvanus Olympio, Université de Lomé, BP. 30785, Lomé, Togo. 3. Service de dermatolgie et IST, CHU Campus Université de Lomé, Lomé, Togo. 4. Centre National de Dermatologie de Gbossimé, Lomé, Togo. 5. Service de Chirurgie Maxillo-faciale et Plastique, CHU Sylvanus Olympio, Université de Lomé, Lomé, Togo. 6. Service de dermatolgie et IST, Centre Hospitalier Régional de Tomdè, Kara, Togo. 7. Service de dermatolgie et IST, CHU Kara, Université de Kara, Kara, Togo. 8. Laboratoire d'anatomie et cytotologie pathologique, CHU Sylvanus Olympio, Université de Lomé, Lomé, Togo.
Abstract
BACKGROUND: In people with albinism (PWA), the deficiency of melanin increase the risk of skin cancers. The aim of this study was to determine the prevalence of skin cancers and characteristics of these detected skin cancers (histological types, localization) in PWA in 10 cities in Togo in 2019. METHODS: This is a cross-sectional study of medical records of PWA systematically examined during two mobile skin care clinics in 2019, as part of a programme for the prevention and management of skin cancers in these subjects. RESULTS: During the study period, 280 (95.2%) of the 294 PWA consulted, had developed skin lesions. Of the 280 PWA, the pathological reports from the medical records of 33 patients (11.8%; (95%CI = [8.2-16.2]) had concluded to non-melanoma skin cancers. The mean age of these 33 patients was 38.6 ± 15.2 years and the sex-ratio was 1. Their occupations were mainly resellers (21.2%), traders (15.2%) and farmers (12.2%). In the 33 patients, 54 cases of non-melanoma skin cancers were identified, with some patients having more than one tumor, and some of them having more than one (histologically confirmed) diagnosis. These 54 non-melanoma skin cancers were divided into 21 cases of invasive squamous cell carcinomas, 2 cases of Bowen's disease and 31 cases of basal cell carcinomas. These non-melanoma skin cancers mainly occurred in the head and neck (33 cases; 61.1%), the upper limbs (15 cases; 27, 8%) and the trunk (4 cases; 7.4%). CONCLUSION: The results of this study show a high prevalence of skin cancers among PWAs in Togo in 2019, only non-melanoma skin cancers. In addition, they illustrate the role of ultraviolet rays with regard to the localization of skin cancers and the occupations of patients. Popularization and compliance with photo protection measures, systematic and regular examination of the skin of these PWAs will allow early detection and treatment of these skin cancers.
BACKGROUND: In people with albinism (PWA), the deficiency of melanin increase the risk of skin cancers. The aim of this study was to determine the prevalence of skin cancers and characteristics of these detected skin cancers (histological types, localization) in PWA in 10 cities in Togo in 2019. METHODS: This is a cross-sectional study of medical records of PWA systematically examined during two mobile skin care clinics in 2019, as part of a programme for the prevention and management of skin cancers in these subjects. RESULTS: During the study period, 280 (95.2%) of the 294 PWA consulted, had developed skin lesions. Of the 280 PWA, the pathological reports from the medical records of 33 patients (11.8%; (95%CI = [8.2-16.2]) had concluded to non-melanoma skin cancers. The mean age of these 33 patients was 38.6 ± 15.2 years and the sex-ratio was 1. Their occupations were mainly resellers (21.2%), traders (15.2%) and farmers (12.2%). In the 33 patients, 54 cases of non-melanoma skin cancers were identified, with some patients having more than one tumor, and some of them having more than one (histologically confirmed) diagnosis. These 54 non-melanoma skin cancers were divided into 21 cases of invasive squamous cell carcinomas, 2 cases of Bowen's disease and 31 cases of basal cell carcinomas. These non-melanoma skin cancers mainly occurred in the head and neck (33 cases; 61.1%), the upper limbs (15 cases; 27, 8%) and the trunk (4 cases; 7.4%). CONCLUSION: The results of this study show a high prevalence of skin cancers among PWAs in Togo in 2019, only non-melanoma skin cancers. In addition, they illustrate the role of ultraviolet rays with regard to the localization of skin cancers and the occupations of patients. Popularization and compliance with photo protection measures, systematic and regular examination of the skin of these PWAs will allow early detection and treatment of these skin cancers.
Entities:
Keywords:
Non-melanoma skin cancers; People with albinism; Togo
Authors: Joseph B Mabula; Phillipo L Chalya; Mabula D Mchembe; Hyasinta Jaka; Geofrey Giiti; Peter Rambau; Nestory Masalu; Erasmus Kamugisha; Ssentongo Robert; Japhet M Gilyoma Journal: BMC Dermatol Date: 2012-06-08