| Literature DB >> 33401533 |
Boris A Katsnelson1, Ivan N Chernyshov1, Svetlana N Solovyeva1, Ilzira A Minigalieva1, Vladimir B Gurvich1, Irene E Valamina2, Oleg H Makeyev2, Renata R Sahautdinova1, Larisa I Privalova1, Anastasia E Tsaregorodtseva2, Artem V Korotkov2, Eugene A Shuman2, Vladimir G Panov1,3, Marina P Sutunkova1.
Abstract
Rats were exposed to nickel oxide nano-aerosol at a concentration of 2.4 ± 0.4 µg/m3 in a "nose only" inhalation setup for 4 h at a time, 5 times a week, during an overall period of 2 weeks to 6 months. Based on the majority of the effects assessed, this kind of exposure may be considered as close to LOAEL (lowest observed adverse effect level), or even to NOAEL (no observed adverse effect level). At the same time, the experiment revealed genotoxic and allergic effects as early as in the first weeks of exposure, suggesting that these effects may have no threshold at all.Entities:
Keywords: allergic sensitization; genotoxicity; inhalation exposure; nickel oxide nanoparticles; pulmonary and systemic toxicity
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Year: 2021 PMID： 33401533 PMCID： PMC7796390 DOI： 10.3390/ijms22010416
Source DB: PubMed Journal: Int J Mol Sci ISSN： 1422-0067 Impact factor: 5.923