| Literature DB >> 33400875 |
Jianning Liao1, Jipan Dong1, Jiaqing Xu1, Wei Wang2, Yongjun Wu2, Yuxia Hou1, Hongchao Guo1.
Abstract
A phosphine-catalyzed [3 + 2] annulation of Morita-Baylis-Hillman (MBH) carbonates with 3-methyl-4-nitro-5-styrylisoxazoles has been developed to afford various multifunctional isoxazoles in moderate to good yields with moderate to excellent diastereoselectivities. With a spirocyclic chiral phosphine as the catalyst, up to 89% ee was obtained.Entities:
Year: 2021 PMID： 33400875 DOI： 10.1021/acs.joc.0c01948
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354