Literature DB >> 33400794

SARS-CoV-2 Seroprevalence Survey Estimates Are Affected by Anti-Nucleocapsid Antibody Decline.

Shelly Bolotin1,2,3, Vanessa Tran1,3, Selma Osman1, Kevin A Brown1,2, Sarah A Buchan1,2, Eugene Joh1, Shelley L Deeks1,2, Vanessa G Allen1,3.   

Abstract

We analyzed 21 676 residual specimens from Ontario, Canada collected March-August 2020 to investigate the effect of antibody decline on SARS-CoV-2 seroprevalence estimates. Testing specimens orthogonally using Abbott (anti-nucleocapsid) and Ortho (anti-spike) assays, seroprevalence estimates were 0.4%-1.4%, despite ongoing disease activity. The geometric mean concentration (GMC) of antibody-positive specimens decreased over time (P = .015), and GMC of antibody-negative specimens increased over time (P = .0018). Association between the 2 tests decreased each month (P < .001), suggesting anti-nucleocapsid antibody decline. Lowering Abbott antibody index cutoff from 1.4 to 0.7 resulted in a 16% increase in positive specimens. © Her Majesty the Queen in Right of Canada, as represented by Ontario Agency for Health Protection and Promotion, 2021.

Entities:  

Keywords:  COVID-19; SARS-CoV-2; serology; seroprevalence

Year:  2021        PMID： 33400794      PMCID： PMC7928877          DOI： 10.1093/infdis/jiaa796

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  14 in total

1.  Ethnoracial Disparities in SARS-CoV-2 Seroprevalence in a Large Cohort of Individuals in Central North Carolina from April to December 2020.

Authors:  Cesar A Lopez; Clark H Cunningham; Sierra Pugh; Katerina Brandt; Usaphea P Vanna; Matthew J Delacruz; Quique Guerra; D Ryan Bhowmik; Samuel J Goldstein; Yixuan J Hou; Margaret Gearhart; Christine Wiethorn; Candace Pope; Carolyn Amditis; Kathryn Pruitt; Cinthia Newberry-Dillon; John L Schmitz; Lakshmanane Premkumar; Adaora A Adimora; Ralph S Baric; Michael Emch; Ross M Boyce; Allison E Aiello; Bailey K Fosdick; Daniel B Larremore; Aravinda M de Silva; Jonathan J Juliano; Alena J Markmann
Journal:  mSphere       Date:  2022-05-19       Impact factor: 5.029

2.  A cohort study measuring SARS-CoV-2 seroconversion and serial viral testing in university students.

Authors:  Christine C Lee; Hannah E Segaloff; Devlin Cole; Hannah G Rosenblum; Clint N Morgan; Tarah Somers; Rodel Desamu-Thorpe; Monique A Foster; Dustin Currie; Jeanne Ruff; David Payne; Thomas J Whyte; Glen R Abedi; John Paul Bigouette; Juliana Kahrs; Kimberly Langolf; Patrick Remington; Alana Sterkel; Patrick Kelly; Ryan P Westergaard; Allen C Bateman; Christopher H Hsu; Jacqueline E Tate; Hannah L Kirking
Journal:  BMC Infect Dis       Date:  2022-03-31       Impact factor: 3.090

3.  Seroprevalence of IgG antibodies against SARS-CoV-2 among the general population and healthcare workers in India, June-July 2021: A population-based cross-sectional study.

Authors:  Manoj V Murhekar; Tarun Bhatnagar; Jeromie Wesley Vivian Thangaraj; V Saravanakumar; Muthusamy Santhosh Kumar; Sriram Selvaraju; Kiran Rade; C P Girish Kumar; R Sabarinathan; Smita Asthana; Rakesh Balachandar; Sampada Dipak Bangar; Avi Kumar Bansal; Jyothi Bhat; Debjit Chakraborty; Vishal Chopra; Dasarathi Das; Kangjam Rekha Devi; Gaurav Raj Dwivedi; Agam Jain; S Muhammad Salim Khan; M Sunil Kumar; Avula Laxmaiah; Major Madhukar; Amarendra Mahapatra; Talluri Ramesh; Chethana Rangaraju; Jyotirmayee Turuk; Suresh Yadav; Balram Bhargava
Journal:  PLoS Med       Date:  2021-12-10       Impact factor: 11.069

4.  Assessment of population infection with SARS-CoV-2 in Ontario, Canada, March to June 2020.

Authors:  Shelly Bolotin; Vanessa Tran; Shelley L Deeks; Adriana Peci; Kevin A Brown; Sarah A Buchan; Katherene Ogbulafor; Tubani Ramoutar; Michelle Nguyen; Rakesh Thakkar; Reynato DelaCruz; Reem Mustfa; Jocelyn Maregmen; Orville Woods; Ted Krasna; Kirby Cronin; Selma Osman; Eugene Joh; Vanessa G Allen
Journal:  Euro Surveill       Date:  2021-12

5.  Rapid Cytokine Release Assays for Analysis of Severe Acute Respiratory Syndrome Coronavirus 2-Specific T Cells in Whole Blood.

Authors:  Andreas Törnell; Hanna Grauers Wiktorin; Johan Ringlander; Mohammad Arabpour; Malin R Nilsson; Staffan Nilsson; Roberta Kiffin; Magnus Lindh; Martin Lagging; Kristoffer Hellstrand; Anna Martner
Journal:  J Infect Dis       Date:  2022-08-24       Impact factor: 7.759

6.  The Influence of Time on the Sensitivity of SARS-CoV-2 Serological Testing.

Authors:  Arturo Torres Ortiz; Fernanda Fenn Torrente; Adam Twigg; James Hatcher; Anja Saso; Tanya Lam; Marina Johnson; Helen Wagstaffe; Rishi Dhillon; Anabelle Lea Mai; David Goldblatt; Rachel Still; Matthew Buckland; Kimberly Gilmour; Louis Grandjean
Journal:  Res Sq       Date:  2022-02-17

7.  Global seroprevalence of SARS-CoV-2 antibodies: A systematic review and meta-analysis.

Authors:  Niklas Bobrovitz; Rahul Krishan Arora; Christian Cao; Emily Boucher; Michael Liu; Claire Donnici; Mercedes Yanes-Lane; Mairead Whelan; Sara Perlman-Arrow; Judy Chen; Hannah Rahim; Natasha Ilincic; Mitchell Segal; Nathan Duarte; Jordan Van Wyk; Tingting Yan; Austin Atmaja; Simona Rocco; Abel Joseph; Lucas Penny; David A Clifton; Tyler Williamson; Cedric P Yansouni; Timothy Grant Evans; Jonathan Chevrier; Jesse Papenburg; Matthew P Cheng
Journal:  PLoS One       Date:  2021-06-23       Impact factor: 3.240

8.  Comparative Assessment of Sera from Individuals after S-Gene RNA-Based SARS-CoV-2 Vaccination with Spike-Protein-Based and Nucleocapsid-Based Serological Assays.

Authors:  Anja Dörschug; Hagen Frickmann; Julian Schwanbeck; Elif Yilmaz; Kemal Mese; Andreas Hahn; Uwe Groß; Andreas E Zautner
Journal:  Diagnostics (Basel)       Date:  2021-03-03

9.  Antibody response after one and two jabs of the BNT162b2 vaccine in nursing home residents: The CONsort-19 study.

Authors:  Hubert Blain; Edouard Tuaillon; Lucie Gamon; Amandine Pisoni; Stéphanie Miot; Yves Rolland; Marie-Christine Picot; Jean Bousquet
Journal:  Allergy       Date:  2021-07-29       Impact factor: 14.710

10.  Lower persistence of anti-nucleocapsid compared to anti-spike antibodies up to one year after SARS-CoV-2 infection.

Authors:  Jan Van Elslande; Matthijs Oyaert; Natalie Lorent; Yannick Vande Weygaerde; Gijs Van Pottelbergh; Lode Godderis; Marc Van Ranst; Emmanuel André; Elizaveta Padalko; Katrien Lagrou; Stien Vandendriessche; Pieter Vermeersch
Journal:  Diagn Microbiol Infect Dis       Date:  2022-02-12       Impact factor: 2.803
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