Ya-Fei Liu1, Zhe Zhang1, Xiao-Li Pan2, Guo-Lan Xing1, Ying Zhang1, Zhang-Suo Liu1, Sheng-Hao Tu3. 1. Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China. 2. College of Acupuncture and Orthopedics, Hubei University of Chinese Medicine, Wuhan, Hubei, China. 3. Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Abstract
BACKGROUND: Currently, the SARS-CoV-2 promptly spread across China and around the world. However, there are controversies about whether preexisting chronic kidney disease (CKD) and acute kidney injury complication (AKI) are involved in the COVID-19 pandemic. MEASUREMENTS: Studies reported the kidney outcomes in different severity of COVID-19 were included in this study. Standardized mean differences or odds ratios were calculated by employing Review Manager meta-analysis software. RESULTS: Thirty-six trials were included in this systematic review with a total of 6395 COVID-19 patients. The overall effects indicated that preexisting CKD (OR = 3.28), complication of AKI (OR = 11.02), serum creatinine (SMD = 0.68), abnormal serum creatinine (OR = 4.86), blood urea nitrogen (SMD = 1.95), abnormal blood urea nitrogen (OR = 6.53), received continuous renal replacement therapy (CRRT) (OR = 23.63) were significantly increased in severe group than that in nonsevere group. Additionally, the complication of AKI (OR = 13.92) and blood urea nitrogen (SMD = 1.18) were remarkably elevated in the critical group than that in the severe group. CONCLUSIONS: CKD and AKI are susceptible to occur in patients with severe COVID-19. CRRT is applied frequently in severe COVID-19 patients than that in nonsevere COVID-19 patients. The risk of AKI is higher in the critical group than that in the severe group.
BACKGROUND: Currently, the SARS-CoV-2 promptly spread across China and around the world. However, there are controversies about whether preexisting chronic kidney disease (CKD) and acute kidney injury complication (AKI) are involved in the COVID-19 pandemic. MEASUREMENTS: Studies reported the kidney outcomes in different severity of COVID-19 were included in this study. Standardized mean differences or odds ratios were calculated by employing Review Manager meta-analysis software. RESULTS: Thirty-six trials were included in this systematic review with a total of 6395 COVID-19patients. The overall effects indicated that preexisting CKD (OR = 3.28), complication of AKI (OR = 11.02), serum creatinine (SMD = 0.68), abnormal serum creatinine (OR = 4.86), blood ureanitrogen (SMD = 1.95), abnormal blood ureanitrogen (OR = 6.53), received continuous renal replacement therapy (CRRT) (OR = 23.63) were significantly increased in severe group than that in nonsevere group. Additionally, the complication of AKI (OR = 13.92) and blood ureanitrogen (SMD = 1.18) were remarkably elevated in the critical group than that in the severe group. CONCLUSIONS:CKD and AKI are susceptible to occur in patients with severe COVID-19. CRRT is applied frequently in severe COVID-19patients than that in nonsevere COVID-19patients. The risk of AKI is higher in the critical group than that in the severe group.
Authors: Marina Treskova-Schwarzbach; Laura Haas; Sarah Reda; Antonia Pilic; Anna Borodova; Kasra Karimi; Judith Koch; Teresa Nygren; Stefan Scholz; Viktoria Schönfeld; Sabine Vygen-Bonnet; Ole Wichmann; Thomas Harder Journal: BMC Med Date: 2021-08-27 Impact factor: 8.775