Jessica Anne Vanderlinden1, Rachel Mary Holden2, Stephen Harold Scott1,3, John Gordon Boyd4,5,6,7. 1. Centre for Neuroscience Studies, Queen's University, Kingston, ON, Canada. 2. Division of Nephrology, Department of Medicine, Queen's University, Kingston, ON, Canada. 3. Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada. 4. Centre for Neuroscience Studies, Queen's University, Kingston, ON, Canada. gordon.boyd@kingstonhsc.ca. 5. Division of Neurology, Department of Medicine, Queen's University, Kingston, ON, Canada. gordon.boyd@kingstonhsc.ca. 6. Department of Critical Care Medicine, Queen's University, Kingston, ON, Canada. gordon.boyd@kingstonhsc.ca. 7. Departments of Medicine (Neurology) and Critical Care Medicine, Kingston General Hospital, Rm 22.2.358 Davies 2, 76 Stuart St, Kingston, ON, K7L 3C9, Canada. gordon.boyd@kingstonhsc.ca.
Abstract
BACKGROUND: Neurocognitive impairment is commonly reported in patients with chronic kidney disease (CKD). The precise nature of this impairment is unclear, due to the lack of objective and quantitative assessment tools used. The feasibility of using robotic technology to precisely quantify neurocognitive impairment in patients with CKD is unknown. METHODS: Patients with stage 4 and 5 CKD with no previous history of stroke or neurodegenerative disease were eligible for study enrollment. Feasibility was defined as successful study enrollment, high data capture rates (> 90%), and assessment tolerability. Our assessment included a traditional assessment: The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), and a robot-based assessment: Kinarm. RESULTS: Our enrollment rate was 1.6 patients/month. All patients completed the RBANS portion of the assessment, with a 97.8% (range 92-100%) completion rate on Kinarm. Missing data on Kinarm were mainly due to time constraints. Data from 49 CKD patients were analyzed. Kinarm defined more individuals as impaired, compared to RBANS, particularly in the domains of perceptual-motor function (17-49% impairment), complex attention (22-49% impairment), and executive function (29-37.5% impairment). Demographic features (sex and education) predicted performance on some, but not all neurocognitive tasks. CONCLUSIONS: It is feasible to quantify neurocognitive impairments in patients with CKD using robotic technology. Kinarm characterized more patients with CKD as impaired, and importantly identified novel perceptual-motor impairments in these patients, when compared to traditional assessments.
BACKGROUND:Neurocognitive impairment is commonly reported in patients with chronic kidney disease (CKD). The precise nature of this impairment is unclear, due to the lack of objective and quantitative assessment tools used. The feasibility of using robotic technology to precisely quantify neurocognitive impairment in patients with CKD is unknown. METHODS:Patients with stage 4 and 5 CKD with no previous history of stroke or neurodegenerative disease were eligible for study enrollment. Feasibility was defined as successful study enrollment, high data capture rates (> 90%), and assessment tolerability. Our assessment included a traditional assessment: The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), and a robot-based assessment: Kinarm. RESULTS: Our enrollment rate was 1.6 patients/month. All patients completed the RBANS portion of the assessment, with a 97.8% (range 92-100%) completion rate on Kinarm. Missing data on Kinarm were mainly due to time constraints. Data from 49 CKDpatients were analyzed. Kinarm defined more individuals as impaired, compared to RBANS, particularly in the domains of perceptual-motor function (17-49% impairment), complex attention (22-49% impairment), and executive function (29-37.5% impairment). Demographic features (sex and education) predicted performance on some, but not all neurocognitive tasks. CONCLUSIONS: It is feasible to quantify neurocognitive impairments in patients with CKD using robotic technology. Kinarm characterized more patients with CKD as impaired, and importantly identified novel perceptual-motor impairments in these patients, when compared to traditional assessments.
Entities:
Keywords:
Chronic kidney disease (CKD); Kinarm; Neurocognitive impairment; The Repeatable Battery for the Neuropsychological Assessment (RBANS)
Authors: Catherine R Lowrey; Sean P Dukelow; Stephen D Bagg; Benjamin Ritsma; Stephen H Scott Journal: Neurorehabil Neural Repair Date: 2022-05-16 Impact factor: 4.895
Authors: Natasha A Jawa; Jessica A Vanderlinden; Stephen H Scott; Jill A Jacobson; Samuel A Silver; Rachel Holden; J Gordon Boyd Journal: Can J Kidney Health Dis Date: 2022-06-14