Gabriela Nazar1, Natalia Ulloa2, María Adela Martínez-Sanguinetti3, Ana María Leiva4, Fanny Petermann-Rocha5, Ximena Díaz Martínez6, Fabian Lanuza7, Igor Cigarroa8, Yeny Concha-Cisternas9, Claudia Troncoso10, Lorena Mardones11, Marcelo Villagrán11, Carlos Celis-Morales5. 1. Departamento de Psicología y Centro Vida Saludable de la Universidad de Concepción, Universidad de Concepción, Concepción, Chile. 2. Departamento de Bioquímica Clínica e Inmunología, Facultad de Farmacia y Centro de Vida Saludable, Universidad de Concepción, Concepción, Chile. 3. Instituto de Farmacia, Facultad de Ciencias, Universidad Austral de Chile, Valdivia, Chile. 4. Instituto de Anatomía, Histología y Patología, Facultad de Medicina, Universidad Austral de Chile, Valdivia, Chile. 5. BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom. 6. Departamento Ciencias de la Educación, Universidad del Biobío, Chillán, Chile. 7. Nutrition and Food Safety Research Institute (INSA), Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona, Spain. 8. Escuela de Kinesiología, Facultad de Salud, Universidad Santo Tomás, Chile. 9. Escuela de Kinesiología, Facultad de Salud, Universidad Santo Tomás, Sede Talca, Sede Talca, Chile. 10. Departamento de Salud Pública, Facultad de Medicina, Universidad Católica de la Santísima Concepción, Concepción, Chile. 11. Departamento de Ciencias Básicas, Universidad Católica de la Santísima Concepción, Concepción, Chile.
Abstract
BACKGROUND: Depression has been previously associated with cognitive impairment in high income country populations. However, its association in the Chilean population has not been investigated. AIM: To investigate the association between depression and cognitive impairment. MATERIAL AND METHODS: Data from 1384 Chilean adults aged > 60 years, participating in the National Health Survey 2009-2010 was analyzed. Cognitive impairment was assessed using the Mini Mental Examination score. The medical diagnosis of depression was self-reported. The association between depression and cognitive impairment was assessed using a logistic regression. RESULTS: Depression was positively associated with cognitive impairment. However, the magnitude of the association was higher in men (Odds ratio (OR) = 4.02 [95% confidence intervals (CI): 1.44; 6.61], p < 0.01]) than in women (OR = 2.23 [95%CI: 1.03; 3.43], p = 0.04). Older adults who were diagnosed for the first time with depression after 65 years of age, showed a stronger association with cognitive impairment (OR = 6.65 [95% CI: 2.39; 10.9], p < 0.01) than those diagnosed before 55 years. CONCLUSIONS: Our study confirms the association between depression and cognitive impairment. Further research is needed to elucidate the nature and potential mechanisms that link depression with cognitive impairment.
BACKGROUND:Depression has been previously associated with cognitive impairment in high income country populations. However, its association in the Chilean population has not been investigated. AIM: To investigate the association between depression and cognitive impairment. MATERIAL AND METHODS: Data from 1384 Chilean adults aged > 60 years, participating in the National Health Survey 2009-2010 was analyzed. Cognitive impairment was assessed using the Mini Mental Examination score. The medical diagnosis of depression was self-reported. The association between depression and cognitive impairment was assessed using a logistic regression. RESULTS:Depression was positively associated with cognitive impairment. However, the magnitude of the association was higher in men (Odds ratio (OR) = 4.02 [95% confidence intervals (CI): 1.44; 6.61], p < 0.01]) than in women (OR = 2.23 [95%CI: 1.03; 3.43], p = 0.04). Older adults who were diagnosed for the first time with depression after 65 years of age, showed a stronger association with cognitive impairment (OR = 6.65 [95% CI: 2.39; 10.9], p < 0.01) than those diagnosed before 55 years. CONCLUSIONS: Our study confirms the association between depression and cognitive impairment. Further research is needed to elucidate the nature and potential mechanisms that link depression with cognitive impairment.
Authors: Carmen Galán-Arroyo; Damián Pereira-Payo; Ángel Denche-Zamorano; Miguel A Hernández-Mocholí; Eugenio Merellano-Navarro; Jorge Pérez-Gómez; Jorge Rojo-Ramos; José Carmelo Adsuar Journal: Int J Environ Res Public Health Date: 2022-03-10 Impact factor: 3.390