M Suppa1,2, M Fontaine1, G Dejonckheere1, E Cinotti3, O Yélamos4,5, G Diet1, L Tognetti3, M Miyamoto1, C Orte Cano1, J Perez-Anker4,6, V Panagiotou7, A L Trepant7, J Monnier8, V Berot9, S Puig4,6, P Rubegni3, J Malvehy4,6, J L Perrot9, V Del Marmol1. 1. Department of Dermatology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. 2. Department of Dermatology, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium. 3. Dermatology Unit, Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy. 4. Melanoma Unit, Hospital Clinic Barcelona, University of Barcelona, Barcelona, Spain. 5. Dermatology Department, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain. 6. CIBER de enfermedades raras, Instituto de Salud Carlos III, Barcelona, Spain. 7. Department of Pathology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. 8. Department of Dermatology, AP-HM, Aix-Marseille University, Marseille, France. 9. Department of Dermatology, University Hospital of Saint-Etienne, Saint-Etienne, France.
Abstract
BACKGROUND: Early diagnosis and subtype classification of basal cell carcinoma (BCC) are crucial to reduce morbidity and optimize treatment. Good accuracy in differentiating BCC from clinical imitators has been achieved with existing diagnostic strategies but lower performance in discriminating BCC subtypes. Line-field confocal optical coherence tomography (LC-OCT) is a new technology able to combine the technical advantages of reflectance confocal microscopy and OCT. OBJECTIVES: To identify and describe LC-OCT criteria associated with BCC and explore their association with BCC subtypes. METHODS: Basal cell carcinoma were imaged with a handheld LC-OCT device before surgical excision. LC-OCT images were retrospectively evaluated by three observers for presence/absence of criteria for BCC. Multivariate logistic regression models were used to find independent predictors of BCC subtypes. RESULTS: Eighty-nine histopathologically proven BCCs were included, of which 66 (74.2%) were pure subtypes [superficial BCC (sBCC): 19/66 (28.8%); nodular BCC (nBCC): 31/66 (47.0%); infiltrative BCC (iBCC): 16/66 (24.2%)]. Lobules, blood vessels and small bright cells within epidermis/lobules were the most frequent criteria for BCC. LC-OCT criteria independently associated with sBCC were presence of hemispheric lobules, absence of lobule separation from the epidermis, absence of stretching of the stroma; with nBCC were presence of macrolobules, absence of lobule connection to the epidermis; and with iBCC were presence of branched lobules. CONCLUSIONS: This was the first study describing the characteristics of BCC under LC-OCT examination. We proposed morphologic criteria, which could be potentially useful for diagnosis and subtype classification of BCC, as well as for its therapeutic management. Future studies are needed to assess these hypotheses.
BACKGROUND: Early diagnosis and subtype classification of basal cell carcinoma (BCC) are crucial to reduce morbidity and optimize treatment. Good accuracy in differentiating BCC from clinical imitators has been achieved with existing diagnostic strategies but lower performance in discriminating BCC subtypes. Line-field confocal optical coherence tomography (LC-OCT) is a new technology able to combine the technical advantages of reflectance confocal microscopy and OCT. OBJECTIVES: To identify and describe LC-OCT criteria associated with BCC and explore their association with BCC subtypes. METHODS:Basal cell carcinoma were imaged with a handheld LC-OCT device before surgical excision. LC-OCT images were retrospectively evaluated by three observers for presence/absence of criteria for BCC. Multivariate logistic regression models were used to find independent predictors of BCC subtypes. RESULTS: Eighty-nine histopathologically proven BCCs were included, of which 66 (74.2%) were pure subtypes [superficial BCC (sBCC): 19/66 (28.8%); nodular BCC (nBCC): 31/66 (47.0%); infiltrative BCC (iBCC): 16/66 (24.2%)]. Lobules, blood vessels and small bright cells within epidermis/lobules were the most frequent criteria for BCC. LC-OCT criteria independently associated with sBCC were presence of hemispheric lobules, absence of lobule separation from the epidermis, absence of stretching of the stroma; with nBCC were presence of macrolobules, absence of lobule connection to the epidermis; and with iBCC were presence of branched lobules. CONCLUSIONS: This was the first study describing the characteristics of BCC under LC-OCT examination. We proposed morphologic criteria, which could be potentially useful for diagnosis and subtype classification of BCC, as well as for its therapeutic management. Future studies are needed to assess these hypotheses.
Authors: Charlotte Gust; Sandra Schuh; Julia Welzel; Fabia Daxenberger; Daniela Hartmann; Lars E French; Cristel Ruini; Elke C Sattler Journal: Cancers (Basel) Date: 2022-02-21 Impact factor: 6.639
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Authors: Sandra Schuh; Cristel Ruini; Maria Katharina Elisabeth Perwein; Fabia Daxenberger; Charlotte Gust; Elke Christina Sattler; Julia Welzel Journal: Cancers (Basel) Date: 2022-02-23 Impact factor: 6.639
Authors: E Cinotti; L Tognetti; A Cartocci; A Lamberti; S Gherbassi; C Orte Cano; C Lenoir; G Dejonckheere; G Diet; M Fontaine; M Miyamoto; J Perez-Anker; V Solmi; J Malvehy; V Del Marmol; J L Perrot; P Rubegni; M Suppa Journal: Clin Exp Dermatol Date: 2021-09-24 Impact factor: 4.481
Authors: Francesco Lacarrubba; Anna Elisa Verzì; Davide Francesco Puglisi; Giuseppe Broggi; Rosario Caltabiano; Giuseppe Micali Journal: J Cutan Pathol Date: 2021-06-10 Impact factor: 1.587