| Literature DB >> 33398872 |
Bo Qin1, Qi Zhang2, Dan Chen2, Hai-Yang Yu2, Ai-Xiang Luo2, Liang-Peng Suo2, Yan Cai3, De-Yang Cai2, Jia Luo2, Ju-Fang Huang2,4, Kun Xiong2,5.
Abstract
Mesenchymal stem cells play an important role in tissue damage and repair. This role is mainly due to a paracrine mechanism, and extracellular vesicles (EVs) are an important part of the paracrine function. EVs play a vital role in many aspects of cell homeostasis, physiology, and pathology, and EVs can be used as clinical biomarkers, vaccines, or drug delivery vehicles. A large number of studies have shown that EVs derived from mesenchymal stem cells (MSC-EVs) play an important role in the treatment of various diseases. However, the problems of low production, low retention rate, and poor targeting of MSC-EVs are obstacles to current clinical applications. The engineering transformation of MSC-EVs can make up for those shortcomings, thereby improving treatment efficiency. This review summarizes the latest research progress of MSC-EV direct and indirect engineering transformation from the aspects of improving MSC-EV retention rate, yield, targeting, and MSC-EV visualization research, and proposes some feasible MSC-EV engineering methods of transformation.Entities:
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Year: 2021 PMID： 33398872 DOI： 10.14670/HH-18-297
Source DB: PubMed Journal: Histol Histopathol ISSN： 0213-3911 Impact factor: 2.303