Simon Nennstiel1, Kathrin Freivogel2, Alexander Faber3, Christoph Schlag3, Bernhard Haller4, Martin Blöchinger5, Markus Dollhopf5, Björn Lewerenz6, Wolfgang Schepp6, Jörg Schirra7, Roland M Schmid3, Bruno Neu8. 1. Medizinische Klinik und Poliklinik Für Innere Medizin II, Klinikum Rechts der Isar der TU München, Ismaninger Str. 22, 81675, Munich, Germany. simon.nennstiel@mri.tum.de. 2. Innere Medizin I, Krankenhaus Barmherzige Brüder München, Romanstraße 93, 80639, Munich, Germany. 3. Medizinische Klinik und Poliklinik Für Innere Medizin II, Klinikum Rechts der Isar der TU München, Ismaninger Str. 22, 81675, Munich, Germany. 4. Institut für Medizinische Informatik, Statistik und Epidemiologie, Klinikum Rechts der Isar der Technischen Universität München, Ismaninger Straße 22, 81675, Munich, Germany. 5. Klinik für Gastroenterologie und Hepatologie, München Klinik Neuperlach (München Klinik gGmbH), Oskar-Maria-Graf-Ring 51, 81737, Munich, Germany. 6. Klinik für Gastroenterologie, Hepatologie und Gastroenterologische Onkologie, München Klinik Bogenhausen (München Klinik gGmbH), Englschalkinger Straße 77, 81925, Munich, Germany. 7. Medizinische Klinik und Poliklinik 2, Klinikum der Universität München Standort Großhadern, Marchioninistraße 15, 81377, Munich, Germany. 8. Medizinische Klinik II, Krankenhaus Landshut-Achdorf, Akademisches Lehrkrankenhaus der TU München, Achdorferweg 3, 84036, Landshut, Germany.
Abstract
BACKGROUND: In patients with altered upper gastrointestinal anatomy, conventional endoscopic retrograde cholangiography is often not possible and different techniques, like enteroscopy-assisted or percutaneous approaches are required. Aim of this study was to analyze success and complication rates of these techniques in a large collective of patients in the daily clinical practice in a pre-endosonographic biliary drainage era. PATIENTS AND METHODS: Patients with altered upper gastrointestinal anatomy with biliary interventions between March 1st, 2006, and June 30th, 2014 in four tertiary endoscopic centers in Munich, Germany were retrospectively analyzed. RESULTS: At least one endoscopic-assisted biliary intervention was successful in 234/411 patients (56.9%)-in 192 patients in the first, in 34 patients in the second and in 8 patients in the third attempt. Success rates for Billroth-II/Whipple-/Roux-en-Y reconstruction were 70.5%/56.7%/49.5%. Complication rates for these reconstructions were 9.3%/6.5%/6.3%, the overall complication rate was 7.1%. Success rates were highest in patients with Billroth-II reconstruction where use of a duodenoscope was possible, complication rates were also highest in this scenario. Success rates were lowest in longer-limb anatomy like Roux-en-Y reconstruction. Percutaneous biliary drainages (PTBD) were inserted 268 times with substantially higher success (90.7%) as well as complication rates (11.6%) compared to the endoscopic approach. Compared to patients treated endoscopically, patients with PTBD had a lower performance status, more severe cholestasis and a significant higher rate of malignant underlying disease. CONCLUSION: In patients with altered upper gastrointestinal anatomy, success rates of endoscopic-assisted biliary interventions are lower compared to PTBD. Still, due to the beneficial complication rates of the endoscopic approach, this technique should be preferred whenever possible and in selected patients who still need to be defined in detail, repeated endoscopic attempts are useful to help achieve the desired result.
BACKGROUND: In patients with altered upper gastrointestinal anatomy, conventional endoscopic retrograde cholangiography is often not possible and different techniques, like enteroscopy-assisted or percutaneous approaches are required. Aim of this study was to analyze success and complication rates of these techniques in a large collective of patients in the daily clinical practice in a pre-endosonographic biliary drainage era. PATIENTS AND METHODS: Patients with altered upper gastrointestinal anatomy with biliary interventions between March 1st, 2006, and June 30th, 2014 in four tertiary endoscopic centers in Munich, Germany were retrospectively analyzed. RESULTS: At least one endoscopic-assisted biliary intervention was successful in 234/411 patients (56.9%)-in 192 patients in the first, in 34 patients in the second and in 8 patients in the third attempt. Success rates for Billroth-II/Whipple-/Roux-en-Y reconstruction were 70.5%/56.7%/49.5%. Complication rates for these reconstructions were 9.3%/6.5%/6.3%, the overall complication rate was 7.1%. Success rates were highest in patients with Billroth-II reconstruction where use of a duodenoscope was possible, complication rates were also highest in this scenario. Success rates were lowest in longer-limb anatomy like Roux-en-Y reconstruction. Percutaneous biliary drainages (PTBD) were inserted 268 times with substantially higher success (90.7%) as well as complication rates (11.6%) compared to the endoscopic approach. Compared to patients treated endoscopically, patients with PTBD had a lower performance status, more severe cholestasis and a significant higher rate of malignant underlying disease. CONCLUSION: In patients with altered upper gastrointestinal anatomy, success rates of endoscopic-assisted biliary interventions are lower compared to PTBD. Still, due to the beneficial complication rates of the endoscopic approach, this technique should be preferred whenever possible and in selected patients who still need to be defined in detail, repeated endoscopic attempts are useful to help achieve the desired result.
Authors: Sumant Inamdar; Eoin Slattery; Divyesh V Sejpal; Larry S Miller; Douglas K Pleskow; Tyler M Berzin; Arvind J Trindade Journal: Gastrointest Endosc Date: 2015-04-25 Impact factor: 9.427
Authors: H Yamamoto; Y Sekine; Y Sato; T Higashizawa; T Miyata; S Iino; K Ido; K Sugano Journal: Gastrointest Endosc Date: 2001-02 Impact factor: 9.427
Authors: Jean-Marc Dumonceau; Andrea Tringali; Ioannis S Papanikolaou; Daniel Blero; Benedetto Mangiavillano; Arthur Schmidt; Geoffroy Vanbiervliet; Guido Costamagna; Jacques Devière; Jesús García-Cano; Tibor Gyökeres; Cesare Hassan; Frédéric Prat; Peter D Siersema; Jeanin E van Hooft Journal: Endoscopy Date: 2018-08-07 Impact factor: 10.093