Julie M Faieta1,2, Hannes Devos3, Prasanna Vaduvathiriyan4, Michele K York5, Kirk I Erickson6, Mark A Hirsch7, Brian G Downer8, Erwin E H van Wegen9, Diana C Wong10, Elena Philippou11, Ahmed Negm12, Pedram Ahmadnezhad3, Shilpa Krishnan13, Melike Kahya3, Pallavi Sood14, Patricia C Heyn15. 1. Department of Rehabilitation, Université Laval, Quebec, Canada. Julie.faieta.1@ulaval.ca. 2. Centre interdisciplinaire de recherche en réadaptation et en intégration sociale (CIRRIS), Québec, Canada. Julie.faieta.1@ulaval.ca. 3. Department of Physical Therapy and Rehabilitation Science, University of Kansas Medical Center, Kansas City, USA. 4. Dykes library, University of Kansas Medical Center, Kansas City, USA. 5. Neurology, Baylor College of Medicine, Houston, USA. 6. Psychology, University of Pittsburgh, Pittsburgh, USA. 7. Physical Medicine and Rehabilitation, Carolinas Medical Center/Carolinas Rehabilitation, Charlotte, USA. 8. Division of Rehabilitation Sciences, School of Health Professions, University of Texas Medical Branch, Galveston, USA. 9. Department of Rehabilitation Medicine, Amsterdam Neurosciences, Amsterdam Movement Sciences, Amsterdam, Netherlands. 10. Occupational Therapy, Rehabilitation Department, New York University, New York, USA. 11. Life and Health Sciences, University of Nicosia, Nicosia, Cyprus. 12. Rehabilitation Medicine, University of Alberta, Edmonton, Canada. 13. Rehabilitation Medicine, Division of Physical Therapy, Emory University, Atlanta, USA. 14. Rehabilitation Science, University of Florida, Gainesville, USA. 15. Physical Medicine and Rehabilitation, University of Colorado Anschutz Medical Campus, Aurora, USA.
Abstract
BACKGROUND: The growing societal and economic impact of Alzheimer's disease (AD) is further compounded by the present lack of disease-modifying interventions. Non-pharmacological intervention approaches, such as exercise, have the potential to be powerful approaches to improve or mitigate the symptoms of AD without added side effects or financial burden associated with drug therapies. Various forms and regiments of exercise (i.e., strength, aerobic, multicomponent) have been reported in the literature; however, conflicting evidence obscures clear interpretation of the value and impact of exercise as an intervention for older adults with AD. The primary objective of this review will be to evaluate the effects of exercise interventions for older adults with AD. In addition, this review will evaluate the evidence quality and synthesize the exercise training prescriptions for proper clinical practice guidelines and recommendations. METHODS: This systematic review and meta-analysis will be carried out by an interdisciplinary collective representing clinical and research stakeholders with diverse expertise related to neurodegenerative diseases and rehabilitation medicine. Literature sources will include the following: Embase, PsychINFO, OVID Medline, and Ovid MEDLINE(R) and Epub Ahead of Print, In-Process & Other Non-Indexed Citations and Daily. Inclusion criteria are participants with late onset AD and structured exercise interventions with prescribed duration, frequency, and intensity. The primary outcome of this study will center on improved or sustained cognitive functioning. Secondary outcomes will include institutionalization-related outcomes, ability in activities of daily living, mood and emotional well-being, quality of life, morbidity, and mortality. Analysis procedures to include measurement of bias, data synthesis, sensitivity analysis, and assessment of heterogeneity are described in this protocol. DISCUSSION: This review is anticipated to yield clinically meaningful insight on the specific value of exercise for older adults with AD. Improved understanding of diverse exercise intervention approaches and their specific impact on various health- and function-related outcomes is expected to guide clinicians to more frequently and accurately prescribe meaningful interventions for those affected by AD. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42020175016 .
BACKGROUND: The growing societal and economic impact of Alzheimer's disease (AD) is further compounded by the present lack of disease-modifying interventions. Non-pharmacological intervention approaches, such as exercise, have the potential to be powerful approaches to improve or mitigate the symptoms of AD without added side effects or financial burden associated with drug therapies. Various forms and regiments of exercise (i.e., strength, aerobic, multicomponent) have been reported in the literature; however, conflicting evidence obscures clear interpretation of the value and impact of exercise as an intervention for older adults with AD. The primary objective of this review will be to evaluate the effects of exercise interventions for older adults with AD. In addition, this review will evaluate the evidence quality and synthesize the exercise training prescriptions for proper clinical practice guidelines and recommendations. METHODS: This systematic review and meta-analysis will be carried out by an interdisciplinary collective representing clinical and research stakeholders with diverse expertise related to neurodegenerative diseases and rehabilitation medicine. Literature sources will include the following: Embase, PsychINFO, OVID Medline, and Ovid MEDLINE(R) and Epub Ahead of Print, In-Process & Other Non-Indexed Citations and Daily. Inclusion criteria are participants with late onset AD and structured exercise interventions with prescribed duration, frequency, and intensity. The primary outcome of this study will center on improved or sustained cognitive functioning. Secondary outcomes will include institutionalization-related outcomes, ability in activities of daily living, mood and emotional well-being, quality of life, morbidity, and mortality. Analysis procedures to include measurement of bias, data synthesis, sensitivity analysis, and assessment of heterogeneity are described in this protocol. DISCUSSION: This review is anticipated to yield clinically meaningful insight on the specific value of exercise for older adults with AD. Improved understanding of diverse exercise intervention approaches and their specific impact on various health- and function-related outcomes is expected to guide clinicians to more frequently and accurately prescribe meaningful interventions for those affected by AD. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42020175016 .
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