| Literature DB >> 33396315 |
Alana Sorgini1, Hugh Andrew Jinwook Kim1, Peter Y F Zeng1, Mushfiq Hassan Shaikh1, Neil Mundi1, Farhad Ghasemi2, Eric Di Gravio1, Halema Khan1, Danielle MacNeil1,3, Mohammed Imran Khan1, Adrian Mendez1,3, John Yoo1,3, Kevin Fung1,3, Pencilla Lang3, David A Palma1,3, Joe S Mymryk1,3,4, John W Barrett1,3, Krupal B Patel5, Paul C Boutros6,7,8,9,10, Anthony C Nichols1,3.
Abstract
Laryngeal squamous cell carcinoma (LSCC) from different subsites have distinct presentations and prognosis. In this study, we carried out a multiomic comparison of LSCC subsites. The Cancer Genome Atlas (TCGA) LSCC cohort was analyzed in the R statistical environment for differences between supraglottic and glottic cancers in single nucleotide variations (SNVs), copy number alterations (CNAs), mRNA abundance, protein abundance, pathway overrepresentation, tumor microenvironment (TME), hypoxia status, and patient outcome. Supraglottic cancers had significantly higher overall and smoking-associated SNV mutational load. Pathway analysis revealed upregulation of muscle related pathways in glottic cancer and neural pathways in supraglottic cancer. Proteins involved in cancer relevant signaling pathways including PI3K/Akt/mTOR, the cell cycle, and PDL1 were differentially abundant between subsites. Glottic and supraglottic tumors have different molecular profiles, which may partially account for differences in presentation and response to therapy.Entities:
Keywords: HNSCC; HPV-negative; genomics; larynx cancer; mutational status
Year: 2020 PMID： 33396315 PMCID： PMC7794818 DOI： 10.3390/cancers13010105
Source DB: PubMed Journal: Cancers (Basel) ISSN： 2072-6694 Impact factor: 6.639