| Literature DB >> 33395624 |
Rameshwari Verma1, Santosh Kumar Verma2, Kadalipura P Rakesh3, Yarabahally R Girish4, Milad Ashrafizadeh5, Kothanahally S Sharath Kumar6, Kanchugarakoppal S Rangappa7.
Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) is becoming lethal to humanity due to easy transmission and difficult-to-treat skin and flimsy diseases. The most threatening aspect is the rapid resistance development of MRSA to any approved antibiotics, including vancomycin. The development of new, efficient, and nontoxic drug candidate to fight against MRSA isolates is the need of the hour. The intriguing molecular structure and versatile bioactive pyrazole core attracting to development required novel antibiotics. This review presents the decade developments of pyrazole-containing derivatives with a broad antibacterial movement against diverged bacterial strains. In specific, we correlated the efficacy of structurally diversified pyrazole analogs against MRSA and discussed different angles of structure-activity relationship (SAR). The current survey highlights pyrazole hybrids' present scenario on MRSA studies, covering articles published from 2011 to 2020. This collective information may become an excellent platform to plan and develop new pyrazole-based small MRSA growth inhibitors with minimal side effects.Entities:
Keywords: Antibiotics; Drug discovery; MRSA; Pyrazole; SAR
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Year: 2020 PMID： 33395624 DOI： 10.1016/j.ejmech.2020.113134
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514