| Literature DB >> 33394241 |
Michelle T Siu1,2,3, Sarah J Goodman3, Isaac Yellan3,4, Darci T Butcher3,5, Maryam Jangjoo3, Daria Grafodatskaya5, Rageen Rajendram3, Youliang Lou3, Rujun Zhang3, Chunhua Zhao3, Rob Nicolson6, Stelios Georgiades7, Peter Szatmari8,9, Stephen W Scherer3,4,10,11, Wendy Roberts3, Evdokia Anagnostou12,13, Rosanna Weksberg14,15,16,17.
Abstract
Many neurodevelopmental disorders (NDDs) share common learning and behavioural impairments, as well as features such as dysregulation of the oxytocin hormone. Here, we examined DNA methylation (DNAm) in the 1st intron of the oxytocin receptor gene, OXTR, in patients with autism spectrum (ASD), attention deficit and hyperactivity (ADHD) and obsessive compulsive (OCD) disorders. DNAm of OXTR was assessed for cohorts of ASD (blood), ADHD (saliva), OCD (saliva), which uncovered sex-specific DNAm differences compared to neurotypical, tissue-matched controls. Individuals with ASD or ADHD exhibiting extreme DNAm values had lower IQ and more social problems, respectively, than those with DNAm within normative ranges. This suggests that OXTR DNAm patterns are altered across NDDs and may be correlated with common clinical outcomes.Entities:
Keywords: ADHD; ASD; DNA methylation; OCD; OXTR
Year: 2021 PMID： 33394241 DOI： 10.1007/s10803-020-04792-x
Source DB: PubMed Journal: J Autism Dev Disord ISSN： 0162-3257